Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease.

COPD gender sex-related differences treatable traits

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
26 Jun 2022
Historique:
received: 10 05 2022
revised: 11 06 2022
accepted: 23 06 2022
entrez: 9 7 2022
pubmed: 10 7 2022
medline: 10 7 2022
Statut: epublish

Résumé

Background: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown. Methods: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differences were tested using t-tests, Mann-Whitney U, or chi-square tests. Results: Frequent exacerbations (30.5 vs. 19.7%), high cardiovascular risk (88.1 vs. 66.2%) and activity-related severe dyspnea (50.9 vs. 34.8%) were more prevalent in women in secondary care (p < 0.05). Severe hyperinflation (43.0 vs. 25.4%), limited diffusing capacity (79.6 vs. 70.1%), impaired mobility (44.0 vs. 28.7%), frequent exacerbations (66.8 vs. 57.4%), frequent hospitalizations (47.5 vs. 41.6%), severe activity-related dyspnea (89.1 vs. 85.0%), symptoms of anxiety (56.3 vs. 42.0%) and depression (50.3 vs. 44.8%), and poor health status (79.9 vs. 71.0%) were more prevalent in women in tertiary care (p < 0.05). Severe inspiratory muscle weakness (14.6 vs. 8.2%) and impaired exercise capacity (69.1 vs. 59.6%) were more prevalent among men (p < 0.05) in tertiary care. Conclusions: Sex-related differences were found, with most traits more prevalent and severe among women. Care providers should be aware of these differences to adjust treatment.

Identifiants

pubmed: 35806965
pii: jcm11133680
doi: 10.3390/jcm11133680
pmc: PMC9267757
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ciro
ID : Ciro+ Short-term Research Training Fellowship 2021
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/BD/146134/2019
Organisme : Fundação para a Ciência e Tecnologia
ID : UIDB/04501/2020

Références

Eur Respir J. 2005 Sep;26(3):511-22
pubmed: 16135736
BMC Public Health. 2012 Aug 02;12:598
pubmed: 22856611
Chest. 2001 Jun;119(6):1691-5
pubmed: 11399692
Aust N Z J Public Health. 2001 Oct;25(5):464-9
pubmed: 11688629
Int J Chron Obstruct Pulmon Dis. 2018 Oct 01;13:3021-3029
pubmed: 30319250
J Clin Med. 2019 Mar 11;8(3):
pubmed: 30862102
Int J Chron Obstruct Pulmon Dis. 2014 Oct 14;9:1145-54
pubmed: 25342899
Int J Chron Obstruct Pulmon Dis. 2020 Apr 23;15:903-919
pubmed: 32425516
Int J Chron Obstruct Pulmon Dis. 2020 Sep 22;15:2217-2224
pubmed: 33061339
Pulmonology. 2021 Jul-Aug;27(4):366-368
pubmed: 32739325
Eur Respir J. 2019 Jun 13;53(6):
pubmed: 30956204
ERJ Open Res. 2020 Nov 02;6(4):
pubmed: 33263050
Eur Respir J. 2014 Dec;44(6):1428-46
pubmed: 25359355
COPD. 2007 Sep;4(3):225-36
pubmed: 17729066
NPJ Prim Care Respir Med. 2017 Dec;27(1):11
pubmed: 28202995
Respir Med. 2006 Oct;100(10):1767-74
pubmed: 16531031
J Thorac Dis. 2018 May;10(Suppl 12):S1390-S1399
pubmed: 29928521
J Thorac Dis. 2015 Oct;7(10):1765-73
pubmed: 26623099
Eur Respir J. 2015 Dec;46(6):1625-35
pubmed: 26453626
Am J Clin Nutr. 1998 Dec;68(6):1298-303
pubmed: 9846862
Eur Respir Rev. 2019 Dec 18;28(154):
pubmed: 31852745
PLoS One. 2012;7(6):e39198
pubmed: 22745715
BMJ Open. 2013 Aug 05;3(8):
pubmed: 23921069
Eur Respir J. 2016 Jul;48(1):46-54
pubmed: 27076595
ERJ Open Res. 2021 May 31;7(2):
pubmed: 34084787
Multidiscip Respir Med. 2015 Aug 05;10(1):24
pubmed: 26246895
J Appl Physiol (1985). 2019 Mar 1;126(3):607-615
pubmed: 30496707
Lancet. 2017 Sep 2;390(10098):988-1002
pubmed: 28872031
Eur Respir J. 2019 May 9;53(5):
pubmed: 30846468
Chest. 1988 Mar;93(3):580-6
pubmed: 3342669
Medicine (Baltimore). 2016 Jul;95(28):e4225
pubmed: 27428228
Br J Clin Pharmacol. 2012 Sep;74(3):396-410
pubmed: 22348281
Respiration. 2019;97(6):548-557
pubmed: 30836374
Eur Respir Rev. 2021 Nov 8;30(162):
pubmed: 34750114
Thorax. 1999 Dec;54(12):1119-38
pubmed: 10567633
Eur Respir J. 2005 Nov;26(5):948-68
pubmed: 16264058
J Psychosom Res. 2002 Feb;52(2):69-77
pubmed: 11832252
Chest. 2005 Oct;128(4):2012-6
pubmed: 16236849
Health Qual Life Outcomes. 2003 Apr 28;1:13
pubmed: 12773199
Am J Cardiol. 1994 Mar 1;73(7):460-8
pubmed: 8141087
Cochrane Database Syst Rev. 2015 Feb 23;(2):CD003793
pubmed: 25705944
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Eur J Clin Nutr. 2020 Aug;74(8):1181-1191
pubmed: 32123345
J Cardiopulm Rehabil. 2003 Mar-Apr;23(2):143-50
pubmed: 12668937
Int J Chron Obstruct Pulmon Dis. 2018 May 10;13:1507-1514
pubmed: 29785100
Eur Respir J. 2017 Jan 3;49(1):
pubmed: 28049168
Am Rev Respir Dis. 1969 May;99(5):696-702
pubmed: 5772056
Am Rev Respir Dis. 1985 Jul;132(1):42-7
pubmed: 4014871
Lancet. 2020 Jul 11;396(10244):97-109
pubmed: 32445693
Int J Chron Obstruct Pulmon Dis. 2019 May 07;14:961-969
pubmed: 31123398
Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64
pubmed: 24127811
Eur Respir J. 1999 Aug;14(2):270-4
pubmed: 10515400
J Psychosom Res. 2017 Jul;98:40-46
pubmed: 28554371
Int J Behav Nutr Phys Act. 2011 Jul 28;8:80
pubmed: 21798044
Eur Respir J. 2009 Sep;34(3):648-54
pubmed: 19720809
BMJ Open. 2018 Apr 10;8(4):e021745
pubmed: 29643168
Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70-e88
pubmed: 31613151
Respir Res. 2019 Aug 22;20(1):191
pubmed: 31439045
J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e11-1097.e24
pubmed: 29169740
Chest. 2019 Jul;156(1):80-91
pubmed: 31034818
Int J Chron Obstruct Pulmon Dis. 2019 Nov 05;14:2469-2478
pubmed: 31806956

Auteurs

Sara Souto-Miranda (S)

Department of Research and Development, Ciro, 6085 NM Horn, The Netherlands.
Respiratory Research and Rehabilitation Laboratory (Lab3R) and Institute of Biomedicine (iBiMED), University of Aveiro, 3810-193 Aveiro, Portugal.
Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.

Alex J van 't Hul (AJ)

Department of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Anouk W Vaes (AW)

Department of Research and Development, Ciro, 6085 NM Horn, The Netherlands.

Jeanine C Antons (JC)

Department of Respiratory Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Remco S Djamin (RS)

Department of Respiratory Diseases, Amphia Hospital, 4818 CK Breda, The Netherlands.

Daisy J A Janssen (DJA)

Department of Research and Development, Ciro, 6085 NM Horn, The Netherlands.
Department of Health Services Research, Care and Public Health Research Institute, Faculty of Health Medicine and Life Sciences, Maastricht University, 6226 NB Maastricht, The Netherlands.

Frits M E Franssen (FME)

Department of Research and Development, Ciro, 6085 NM Horn, The Netherlands.
Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.

Alda Marques (A)

Respiratory Research and Rehabilitation Laboratory (Lab3R) and Institute of Biomedicine (iBiMED), University of Aveiro, 3810-193 Aveiro, Portugal.

Martijn A Spruit (MA)

Department of Research and Development, Ciro, 6085 NM Horn, The Netherlands.
Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The Netherlands.

Classifications MeSH