Carnosic Acid Encapsulated in Albumin Nanoparticles Induces Apoptosis in Breast and Colorectal Cancer Cells.
BCL-2
COX-2
GCLC
bovine serum albumin nanoparticles
carnosic acid (CA)
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Jun 2022
25 Jun 2022
Historique:
received:
07
05
2022
revised:
16
06
2022
accepted:
17
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Carnosic acid (CA) is a natural phenolic compound with several biomedical actions. This work was performed to study the use of CA-loaded polymeric nanoparticles to improve the antitumor activity of breast cancer cells (MCF-7) and colon cancer cells (Caco-2). CA was encapsulated in bovine serum albumin (BSA), chitosan (CH), and cellulose (CL) nanoparticles. The CA-loaded BSA nanoparticles (CA-BSA-NPs) revealed the most promising formula as it showed good loading capacity and the best release rate profile as the drug reached 80% after 10 h. The physicochemical characterization of the CA-BSA-NPs and empty carrier (BSA-NPs) was performed by the particle size distribution analysis, transmission electron microscopy (TEM), and zeta potential. The antitumor activity of the CA-BSA-NPs was evaluated by measuring cell viability, apoptosis rate, and gene expression of GCLC, COX-2, and BCL-2 in MCF-7 and Caco-2. The cytotoxicity assay (MTT) showed elevated antitumor activity of CA-BSA-NPs against MCF-7 and Caco-2 compared to free CA and BSA-NPs. Moreover, apoptosis test data showed an arrest of the Caco-2 cells at G
Identifiants
pubmed: 35807348
pii: molecules27134102
doi: 10.3390/molecules27134102
pmc: PMC9268188
pii:
doi:
Substances chimiques
Abietanes
0
Drug Carriers
0
Proto-Oncogene Proteins c-bcl-2
0
Serum Albumin, Bovine
27432CM55Q
Cyclooxygenase 2
EC 1.14.99.1
salvin
LI791SXT24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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