Computation Screening of Multi-Target Antidiabetic Properties of Phytochemicals in Common Edible Mediterranean Plants.
DIA-DB web server
antidiabetic activity
diabetes
flavonoids
in silico study
mechanism of action
phenolic acids
terpenes
Journal
Plants (Basel, Switzerland)
ISSN: 2223-7747
Titre abrégé: Plants (Basel)
Pays: Switzerland
ID NLM: 101596181
Informations de publication
Date de publication:
21 Jun 2022
21 Jun 2022
Historique:
received:
30
05
2022
revised:
09
06
2022
accepted:
16
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
10
7
2022
Statut:
epublish
Résumé
Diabetes mellitus is a metabolic disease and one of the leading causes of deaths worldwide. Numerous studies support that the Mediterranean diet has preventive and treatment effects on diabetes. These effects have been attributed to the special bioactive composition of Mediterranean foods. The objective of this work was to decipher the antidiabetic activity of Mediterranean edible plant materials using the DIA-DB inverse virtual screening web server. A literature review on the antidiabetic potential of Mediterranean plants was performed and twenty plants were selected for further examination. Subsequently, the most abundant flavonoids, phenolic acids, and terpenes in plant materials were studied to predict their antidiabetic activity. Results showed that flavonoids are the most active phytochemicals as they modulate the function of 17 protein-targets and present high structural similarity with antidiabetic drugs. Their antidiabetic effects are linked with three mechanisms of action, namely (i) regulation of insulin secretion/sensitivity, (ii) regulation of glucose metabolism, and (iii) regulation of lipid metabolism. Overall, the findings can be utilized to understand the antidiabetic activity of edible Mediterranean plants pinpointing the most active phytoconstituents.
Identifiants
pubmed: 35807588
pii: plants11131637
doi: 10.3390/plants11131637
pmc: PMC9269125
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Cyprus University of Technology
ID : EX200146
Organisme : FUNDACIÓN SÉNECA DE LA REGIÓN DE MURCIA
ID : 20988/PI/18
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