Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN ('Seguimiento Universidad de Navarra') Project.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
21 Jun 2022
Historique:
received: 27 05 2022
revised: 17 06 2022
accepted: 19 06 2022
entrez: 9 7 2022
pubmed: 10 7 2022
medline: 14 7 2022
Statut: epublish

Résumé

Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HR

Identifiants

pubmed: 35807746
pii: nu14132561
doi: 10.3390/nu14132561
pmc: PMC9268452
pii:
doi:

Substances chimiques

Vitamins 0
Vitamin D 1406-16-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564
Organisme : European Regional Development Fund (FEDER)
ID : RD 06/0045
Organisme : Comunidad Foral de Navarra
ID : 27/2011, 45/2011, 122/2014

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Auteurs

Rodrigo Sánchez-Bayona (R)

Medical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.

Maira Bes-Rastrollo (M)

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Cesar I Fernández-Lázaro (CI)

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Maite Bastyr (M)

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.

Ainhoa Madariaga (A)

Medical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.

Juan J Pons (JJ)

IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Department of History, Art History, and Geography, University of Navarra, 31008 Pamplona, Spain.

Miguel A Martínez-González (MA)

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Estefanía Toledo (E)

Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.
Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

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Classifications MeSH