The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations.
Selenium
Selenium pathway
case–control cohorts
colorectal cancer risk
colorectal neoplasms
selenoprotein gene variation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Jun 2022
29 Jun 2022
Historique:
received:
09
06
2022
accepted:
27
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case-control cohort. We tested if significantly associated selenoprotein gene SNPs from these studies were also associated with CRC risk in case-control studies from Ireland (colorectal neoplasia, i.e., cancer and adenoma cases: 450, controls: 461) and the Czech Republic (CRC cases: 718, controls: 646). Genotyping of 23 SNPs (20 in the Irish and 13 in the Czechs) was performed by competitive specific allele-specific PCR (KASPar). Multivariable adjusted logistic regression was used to assess the associations with CRC development. We found significant associations with an increased CRC risk for rs5859 ( Several SNPs previously associated with CRC risk were also associated with CRC or colorectal neoplasia development in either the Irish or Czech cohorts. Selenoprotein gene variation may modify CRC risk across diverse European populations, although the specific variants may differ.
Sections du résumé
BACKGROUND
BACKGROUND
Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case-control cohort.
METHODS
METHODS
We tested if significantly associated selenoprotein gene SNPs from these studies were also associated with CRC risk in case-control studies from Ireland (colorectal neoplasia, i.e., cancer and adenoma cases: 450, controls: 461) and the Czech Republic (CRC cases: 718, controls: 646). Genotyping of 23 SNPs (20 in the Irish and 13 in the Czechs) was performed by competitive specific allele-specific PCR (KASPar). Multivariable adjusted logistic regression was used to assess the associations with CRC development.
RESULTS
RESULTS
We found significant associations with an increased CRC risk for rs5859 (
CONCLUSIONS
CONCLUSIONS
Several SNPs previously associated with CRC risk were also associated with CRC or colorectal neoplasia development in either the Irish or Czech cohorts. Selenoprotein gene variation may modify CRC risk across diverse European populations, although the specific variants may differ.
Identifiants
pubmed: 35807897
pii: nu14132718
doi: 10.3390/nu14132718
pmc: PMC9268344
pii:
doi:
Substances chimiques
Selenoprotein P
0
Selenoproteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Health Research Board of Ireland
ID : HRA-POS/2013/397
Organisme : International Hundred K+ Cohorts Consortium/Global Genomic Medicine Collaborative (IHCC/G2MC)
ID : 31312020
Organisme : Czech Science Foundation
ID : GACR 20-03997S
Organisme : Czech Science Foundation
ID : VV 22-05942S
Organisme : Czech Health Research council of the Ministry of Health of the Czech Republic
ID : AZV NV18-03-00199
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