A mass-balance approach to evaluate arsenic intake and excretion in different populations.
Arsenic
Sources of exposure
Urine
Well water
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
13
03
2022
revised:
19
06
2022
accepted:
22
06
2022
medline:
23
10
2023
pubmed:
10
7
2022
entrez:
9
7
2022
Statut:
ppublish
Résumé
Unless a toxicant builds up in a deep compartment, intake by the human body must on average balance the amount that is lost. We apply this idea to assess arsenic (As) exposure misclassification in three previously studied populations in rural Bangladesh (n = 11,224), Navajo Nation in the Southwestern United States (n = 619), and northern Chile (n = 630), under varying assumptions about As sources. Relationships between As intake and excretion were simulated by taking into account additional sources, as well as variability in urine dilution inferred from urinary creatinine. The simulations bring As intake closer to As excretion but also indicate that some exposure misclassification remains. In rural Bangladesh, accounting for intake from more than one well and rice improved the alignment of intake and excretion, especially at low exposure. In Navajo Nation, comparing intake and excretion revealed home dust as an important source. Finally, in northern Chile, while food-frequency questionnaires and urinary As speciation indicate fish and shellfish sources, persistent imbalance of intake and excretion suggests imprecise measures of drinking water arsenic as a major cause of exposure misclassification. The mass-balance approach could prove to be useful for evaluating sources of exposure to toxicants in other settings.
Identifiants
pubmed: 35809487
pii: S0160-4120(22)00298-7
doi: 10.1016/j.envint.2022.107371
pmc: PMC9790973
mid: NIHMS1827825
pii:
doi:
Substances chimiques
Arsenic
N712M78A8G
Drinking Water
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
107371Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES004705
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010349
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES025589
Pays : United States
Organisme : NIMHD NIH HHS
ID : P50 MD015706
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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