The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications.

Nitric Oxide / metabolism Proteins / metabolism S-Nitrosothiols Sulfhydryl Compounds
Hydrogen sulfide Hydropersuflides Nitric oxide Nitroxyl S-Nitrosothiols S-Thiolation Transnitrosation

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
01 08 2022
Historique:
received: 03 05 2022
revised: 06 06 2022
accepted: 29 06 2022
pubmed: 10 7 2022
medline: 20 7 2022
entrez: 9 7 2022
Statut: ppublish

Résumé

S-Nitrosothiol (RS-NO) generation/levels have been implicated as being important to numerous physiological and pathophysiological processes. As such, the mechanism(s) of their generation and degradation are important factors in determining their biological activity. Along with the effects on the activity of thiol proteins, RS-NOs have also been reported to be reservoirs or storage forms of nitric oxide (NO). That is, it is hypothesized that NO can be released from RS-NO at opportune times to, for example, regulate vascular tone. However, to date there are few established mechanisms that can account for facile NO release from RS-NO. Recent discovery of the biological formation and prevalence of hydropersulfides (RSSH) and their subsequent reaction with RS-NO species provides a possible route for NO release from RS-NO. Herein, it is found that RSSH is capable of reacting with RS-NO to liberate NO and that the analogous reaction using RSH is not nearly as proficient in generating NO. Moreover, computational results support the prevalence of this reaction over other possible competing processes. Finally, results of biological studies of NO-mediated vasorelaxation are consistent with the idea that RS-NO species can be degraded by RSSH to release NO.

Identifiants

DOI: 10.1016/j.freeradbiomed.2022.06.245 PMID: 35809768
pubmed: 35809768
pii: S0891-5849(22)00472-5
doi: 10.1016/j.freeradbiomed.2022.06.245
pii:
doi:

Substances chimiques

Proteins 0
S-Nitrosothiols 0
Sulfhydryl Compounds 0
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

459-467

Subventions

Organisme : British Heart Foundation
ID : RG/16/7/32357
Pays : United Kingdom

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Jessica Zarenkiewicz (J)

Department of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA.

Christina Perez-Ternero (C)

William Harvey Research Institute, Barts & The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

Volga Kojasoy (V)

Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA.

Christopher McGinity (C)

William Harvey Research Institute, Barts & The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

Vinayak S Khodade (VS)

Department of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA.

Joseph Lin (J)

Department of Biology, Sonoma State University, Rohnert Park, CA, 94928, USA.

Dean J Tantillo (DJ)

Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA. Electronic address: djtantillo@ucdavis.edu.

John P Toscano (JP)

Department of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA. Electronic address: jtoscano@jhu.edu.

Adrian J Hobbs (AJ)

William Harvey Research Institute, Barts & The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. Electronic address: aj.hobbs@qmul.ac.uk.

Jon M Fukuto (JM)

Department of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA. Electronic address: fukuto@sonoma.edu.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › The reaction of hydropersulfides (RSSH) with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › The reaction of hydropersulfides (RSSH) with...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › S-Nitrosothiols › The reaction of hydropersulfides (RSSH) with...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiols › The reaction of hydropersulfides (RSSH) with...