Development of Ferroptosis-Associated ceRNA Network in Periodontitis.
Ferroptosis
Noncoding RNA
Periodontitis
ceRNA network
Journal
International dental journal
ISSN: 1875-595X
Titre abrégé: Int Dent J
Pays: England
ID NLM: 0374714
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
09
04
2022
revised:
05
05
2022
accepted:
07
05
2022
pubmed:
10
7
2022
medline:
15
3
2023
entrez:
9
7
2022
Statut:
ppublish
Résumé
Periodontitis is a chronic inflammatory illness that may lead to tooth loosening and even loss, and its pathogenesis is not fully understood. Ferroptosis is an iron-dependent, regulated cell death. The present study aims to find the key ferroptosis-related genes (FRGs) in periodontitis and develop an mRNA-miRNA-lncRNA network to deeply explore the pathogenesis of periodontitis. Data from the Gene Expression Omnibus (GEO) database and FerrDb database were downloaded to discover the differentially expressed mRNA, miRNA, and FRGs. Functional enrichment analysis was conducted for the differentially expressed FRGs (DE-FRGs), including gene ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and protein-protein interaction (PPI) network analysis. Targetscan and miRtarbase were used to estimate the miRNAs that DE-FRGs may interact with, whilst StarBase v3.0 was used for lncRNA-miRNA interaction. Seven DE-FRGs were identified through differential expression analysis. Interleukin 1 beta (IL1B) interacted with XBP1 and MMP13 in the PPI network. After taking the intersection between DE-miRNAs and predicted miRNAs, a ceRNA network containing IL1B, has-miR-185, has-miR-204, has-miR-211, has-miR-4306, and 28 lncRNAs was established. Seven FRGs in periodontitis were identified, which might promote deeper understanding of ferroptosis in periodontitis.
Identifiants
pubmed: 35810010
pii: S0020-6539(22)00106-X
doi: 10.1016/j.identj.2022.05.004
pmc: PMC10023542
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
MicroRNAs
0
RNA, Messenger
0
MIRN204 microRNA, human
0
MIRN4306 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-194Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest None disclosed.
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