ESCRTed resistance to T cell attack.

Endosomal Sorting Complexes Required for Transport / metabolism Endosomes / metabolism Humans Protein Transport

Journal

Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032

Informations de publication

Date de publication:
08 2022
Historique:
received: 11 06 2022
accepted: 26 06 2022
pubmed: 10 7 2022
medline: 3 8 2022
entrez: 9 7 2022
Statut: ppublish

Résumé

Cytotoxic T cells kill target cells such as cancer cells by making pores in their plasma membrane through which toxic enzymes are secreted. Ritter and colleagues now show that cancer cells can actively remove such pores via the action of endosomal sorting complex required for transport (ESCRT) proteins, thereby counteracting CD8

Identifiants

DOI: 10.1016/j.it.2022.06.007 PMID: 35810056
pubmed: 35810056
pii: S1471-4906(22)00136-3
doi: 10.1016/j.it.2022.06.007
pii:
doi:

Substances chimiques

Endosomal Sorting Complexes Required for Transport 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

598-600

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no conflicts of interest.

Auteurs

Simona Maria Migliano (SM)

Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.

Harald Stenmark (H)

Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Faculty of Medicine, N-7491 Trondheim, Norway. Electronic address: stenmark@ulrik.uio.no.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Complexes de tri endosomique requis pour le transport › ESCRTed resistance to T cell attack.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › ESCRTed resistance to T cell attack.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ESCRTed resistance to T cell attack.
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › ESCRTed resistance to T cell attack.