Developing an experimental model of early knee osteoarthritis after medial meniscus posterior root release: an in vivo study.
Animal model
Early osteoarthritis
Knee osteoarthritis
Meniscal root tear
Rabbit model
Journal
Journal of experimental orthopaedics
ISSN: 2197-1153
Titre abrégé: J Exp Orthop
Pays: Germany
ID NLM: 101653750
Informations de publication
Date de publication:
09 Jul 2022
09 Jul 2022
Historique:
received:
12
04
2022
accepted:
21
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
10
7
2022
Statut:
epublish
Résumé
To develop a predictable and reproducible model of knee osteoarthritis after medial meniscus posterior root release. Posteromedial meniscal root tears were created in 12 White New Zealand rabbit knees. The contralateral limbs were used as healthy controls. The animals were euthanized at 16 weeks postoperatively; tissue samples of femoral and tibial articular cartilage were collected and processed for macro and microscopic analyses to detect signs of early degeneration. Clinical evaluation of the weight-bearing status on the affected knee was conducted at 0-, 4-, 8-, and 16-weeks postoperatively. Early and severe osteoarthritic changes were the hallmark and the main findings after 16-weeks post-surgery. Macroscopically, extensive osteoarthritic changes were observed across the femoral condyle and tibial plateau. Microscopic finding included ulcerations, fissures, fibrillations, pitting, and loss of the superficial layer. Cellularity was diminished, the normal pattern of distribution in columns was lost, and subchondral bone exposure was also evident. This study describes a novel model of knee osteoarthritis that may guide the development of tailored interventions to delay or prevent knee osteoarthritis. This knowledge could shift the current treatment paradigm toward more conservative and knee salvageable treatment options and increase surgeons' awareness of this injury pattern. Such considerations may have a positive impact on clinical decision-making and subsequent patient-reported clinical outcomes. Controlled laboratory study. II.
Identifiants
pubmed: 35810237
doi: 10.1186/s40634-022-00501-y
pii: 10.1186/s40634-022-00501-y
pmc: PMC9271147
doi:
Types de publication
Journal Article
Langues
eng
Pagination
66Informations de copyright
© 2022. The Author(s).
Références
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