DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
09 07 2022
Historique:
received: 09 12 2021
accepted: 23 06 2022
entrez: 9 7 2022
pubmed: 10 7 2022
medline: 14 7 2022
Statut: epublish

Résumé

This work demonstrates and guides how to use a range of state-of-the-art artificial neural-networks to analyse bacterial microscopy images using the recently developed ZeroCostDL4Mic platform. We generated a database of image datasets used to train networks for various image analysis tasks and present strategies for data acquisition and curation, as well as model training. We showcase different deep learning (DL) approaches for segmenting bright field and fluorescence images of different bacterial species, use object detection to classify different growth stages in time-lapse imaging data, and carry out DL-assisted phenotypic profiling of antibiotic-treated cells. To also demonstrate the ability of DL to enhance low-phototoxicity live-cell microscopy, we showcase how image denoising can allow researchers to attain high-fidelity data in faster and longer imaging. Finally, artificial labelling of cell membranes and predictions of super-resolution images allow for accurate mapping of cell shape and intracellular targets. Our purposefully-built database of training and testing data aids in novice users' training, enabling them to quickly explore how to analyse their data through DL. We hope this lays a fertile ground for the efficient application of DL in microbiology and fosters the creation of tools for bacterial cell biology and antibiotic research.

Identifiants

pubmed: 35810255
doi: 10.1038/s42003-022-03634-z
pii: 10.1038/s42003-022-03634-z
pmc: PMC9271087
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

688

Subventions

Organisme : Wellcome Trust
ID : 203276/Z/16/Z
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

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Auteurs

Christoph Spahn (C)

Department of Natural Products in Organismic Interaction, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. christoph.spahn@mpi-marburg.mpg.de.
Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany. christoph.spahn@mpi-marburg.mpg.de.

Estibaliz Gómez-de-Mariscal (E)

Instituto Gulbenkian de Ciência, 2780-156, Oeiras, Portugal.

Romain F Laine (RF)

MRC-Laboratory for Molecular Cell Biology, University College London, London, UK.
The Francis Crick Institute, London, UK.
Micrographia Bio, Translation and Innovation hub 84 Wood lane, W120BZ, London, UK.

Pedro M Pereira (PM)

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.

Lucas von Chamier (L)

MRC-Laboratory for Molecular Cell Biology, University College London, London, UK.

Mia Conduit (M)

Centre for Bacterial Cell Biology, Newcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne, NE24AX, United Kingdom.

Mariana G Pinho (MG)

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.

Guillaume Jacquemet (G)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.
Turku Bioimaging, University of Turku and Åbo Akademi University, Turku, Finland.

Séamus Holden (S)

Centre for Bacterial Cell Biology, Newcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne, NE24AX, United Kingdom.

Mike Heilemann (M)

Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany. heilemann@chemie.uni-frankfurt.de.

Ricardo Henriques (R)

Instituto Gulbenkian de Ciência, 2780-156, Oeiras, Portugal. rjhenriques@igc.gulbenkian.pt.
MRC-Laboratory for Molecular Cell Biology, University College London, London, UK. rjhenriques@igc.gulbenkian.pt.
The Francis Crick Institute, London, UK. rjhenriques@igc.gulbenkian.pt.

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