Therapeutic potential of recombinant human basic fibroblast growth factor on postoperative patients with chronic rhinosinusitis with nasal polyps.
eosinophilic chronic rhinosinusitis
nasal mucosa
nasal-drop
nasal-spray
rh-bFGF
Journal
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
ISSN: 1749-4486
Titre abrégé: Clin Otolaryngol
Pays: England
ID NLM: 101247023
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
31
05
2022
received:
27
03
2022
accepted:
12
06
2022
pubmed:
11
7
2022
medline:
22
2
2023
entrez:
10
7
2022
Statut:
ppublish
Résumé
To explore the effect of intranasal administration of recombinant human basic fibroblast growth factor (rh-bFGF) on postoperative chronic rhinosinusitis with nasal polyps (CRSwNP) patients. A prospective, randomised, controlled, single-blinded trial. Seventy-five hospitalised patients who met the criteria of primary bilateral CRSwNP were enrolled from March 2020 to January 2021. Visual analogue scale, 22-item Sino-Nasal Outcome Test, Lund-Kennedy (L-K) system and scanning electron microscopy and quantitative real-time polymerase chain reaction. Seventy-five patients with CRSwNP were randomly assigned to three groups, and 72 patients completed the 1-month medication regimen and 1-year follow-up. Rh-bFGF nasal-spray and drop application reduced general nasal VAS scores within 2 weeks after endoscopic sinus surgery (ESS) compared to the control group. In contrast, only rh-bFGF nasal-drops reduced SNOT-22 scores at 2 weeks and 1 year compared with the control group. A significant reduction in the endoscopic L-K score was observed in the rh-bFGF nasal-spray and drop group compared with the control group. This is primarily because rh-bFGF promotes cilia growth in the nasal mucosal epithelium after the operation, as illustrated by scanning electron microscopy and expression of CP110, Tap73 and Foxj1 mRNA. For eosinophilic CRSwNP, the general VAS score of rh-bFGF nasal-drops was more obviously reduced compared to the control group after ESS. A similar trend was observed for L-K score. Rh-bFGF nasal-drops and sprays can quickly and effectively relieve postoperative symptoms and improve long-term prognosis of patients with CRSwNP. Moreover, rh-bFGF nasal-drops is also an effective method for postoperative patients with eosinophilic CRSwNP.
Substances chimiques
KCB-1 protein, recombinant
0
Nasal Sprays
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
294-304Subventions
Organisme : Medical Science and Technology Foundation of Guangdong Province
ID : A2018334
Organisme : National Natural Science Foundation of China
ID : 82000950
Organisme : Natural Science Foundation of Guangdong Province
ID : 2018A030313620
Organisme : Science and Technology Planing Program of Guangzhou
ID : 202201020067
Informations de copyright
© 2022 The Authors. Clinical Otolaryngology published by John Wiley & Sons Ltd.
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