Cross talk mechanism of disturbed sleep patterns in neurological and psychological disorders.
Antidepressant drugs
Circadian rhythm
Neurodegenerative disorders
Neuropsychiatric disorders
Signaling
Sleep disorders
Therapeutics
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
29
04
2022
revised:
20
06
2022
accepted:
01
07
2022
pubmed:
11
7
2022
medline:
31
8
2022
entrez:
10
7
2022
Statut:
ppublish
Résumé
The incidence and prevalence of sleep disorders continue to increase in the elderly populace, particularly those suffering from neurodegenerative and neuropsychiatric disorders. This not only affects the quality of life but also accelerates the progression of the disease. There are many reasons behind sleep disturbances in such patients, for instance, medication use, nocturia, obesity, environmental factors, nocturnal motor disturbances and depressive symptoms. This review focuses on the mechanism and effects of sleep dysfunction in neurodegenerative and neuropsychiatric disorders. Wherein we discuss disturbed circadian rhythm, signaling cascade and regulation of genes during sleep deprivation. Moreover, we explain the perturbation in brainwaves during disturbed sleep and the ocular perspective of neurodegenerative and neuropsychiatric manifestations in sleep disorders. Further, as the pharmacological approach is often futile and carries side effects, therefore, the non-pharmacological approach opens newer possibilities to treat these disorders and widens the landscape of treatment options for patients.
Identifiants
pubmed: 35811007
pii: S0149-7634(22)00256-1
doi: 10.1016/j.neubiorev.2022.104767
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104767Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.