Genetic liability to posttraumatic stress disorder and its association with postpartum depression.

Infant, Newborn Female Humans Depression, Postpartum / epidemiology Depressive Disorder, Major / epidemiology Stress Disorders, Post-Traumatic / epidemiology Case-Control Studies Risk Factors Postpartum Period / psychology
Childbirth genetics postpartum depression posttraumatic stress disorder

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
08 2023
Historique:
medline: 1 9 2023
pubmed: 12 7 2022
entrez: 11 7 2022
Statut: ppublish

Résumé

Childbirth may be a traumatic experience and vulnerability to posttraumatic stress disorder (PTSD) may increase the risk of postpartum depression (PPD). We investigated whether genetic vulnerability to PTSD as measured by polygenic score (PGS) increases the risk of PPD and whether a predisposition to PTSD in PPD cases exceeds that of major depressive disorder (MDD) outside the postpartum period. This case-control study included participants from the iPSYCH2015, a case-cohort of all singletons born in Denmark between 1981 and 2008. Restricting to women born between 1981 and 1997 and excluding women with a first diagnosis other than depression ( The PTSD PGS was significantly associated with PPD (OR 1.42, 95% CI 1.20-1.68 per standard deviation increase in PTSD PGS) compared to healthy female controls. Genetic PTSD vulnerability in PPD cases did not exceed that of matched female depression cases outside the postpartum period (OR 1.10, 95% CI 0.94-1.30 per standard deviation increase). Genetic vulnerability to PTSD increased the risk of PPD but did not differ between PPD cases and women with depression at other times.

Sections du résumé

BACKGROUND
Childbirth may be a traumatic experience and vulnerability to posttraumatic stress disorder (PTSD) may increase the risk of postpartum depression (PPD). We investigated whether genetic vulnerability to PTSD as measured by polygenic score (PGS) increases the risk of PPD and whether a predisposition to PTSD in PPD cases exceeds that of major depressive disorder (MDD) outside the postpartum period.
METHODS
This case-control study included participants from the iPSYCH2015, a case-cohort of all singletons born in Denmark between 1981 and 2008. Restricting to women born between 1981 and 1997 and excluding women with a first diagnosis other than depression (
RESULTS
The PTSD PGS was significantly associated with PPD (OR 1.42, 95% CI 1.20-1.68 per standard deviation increase in PTSD PGS) compared to healthy female controls. Genetic PTSD vulnerability in PPD cases did not exceed that of matched female depression cases outside the postpartum period (OR 1.10, 95% CI 0.94-1.30 per standard deviation increase).
CONCLUSIONS
Genetic vulnerability to PTSD increased the risk of PPD but did not differ between PPD cases and women with depression at other times.

Identifiants

DOI: 10.1017/S0033291722002045 PMID: 35811373
pubmed: 35811373
doi: 10.1017/S0033291722002045
pii: S0033291722002045
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5052-5059

Subventions

Organisme : NIMH NIH HHS
ID : U01 MH109514
Pays : United States

Auteurs

Kathrine Bang Madsen (K)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
ORCID: 0000-0002-0103-5534

Xiaoqin Liu (X)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.

Clara Albiñana (C)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.

Bjarni Jóhann Vilhjálmsson (B)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.

Esben Agerbo (E)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
CIRRAU - Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.

Preben Bo Mortensen (PB)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
CIRRAU - Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.

David Michael Hougaard (DM)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

Merete Nordentoft (M)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Thomas Werge (T)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.
Lundbeck Foundation Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.

Ole Mors (O)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.

Anders D Børglum (AD)

iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Department of Biomedicine and the iSEQ Center, Aarhus University, Aarhus, Denmark.
Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.

Trine Munk-Olsen (T)

NCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Research Unit of Psychiatry, Institute for Clinical Research, University of Southern Denmark, Odense, Denmark.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Dépression du postpartum › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Genetic liability to posttraumatic stress...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Période du postpartum › Genetic liability to posttraumatic stress...