Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?
DNA damage response (DDR)
cardiac mesenchymal stromal cells
heart failure
heart failure with preserved ejection fraction (HFpEF)
mechanical stretch effects
pressure overload
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
02
2022
accepted:
17
05
2022
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
12
7
2022
Statut:
epublish
Résumé
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome characterized by impaired left ventricular (LV) diastolic function, with normal LV ejection fraction. Aortic valve stenosis can cause an HFpEF-like syndrome by inducing sustained pressure overload (PO) and cardiac remodeling, as cardiomyocyte (CM) hypertrophy and fibrotic matrix deposition. Recently,
Identifiants
pubmed: 35811699
doi: 10.3389/fcvm.2022.878268
pmc: PMC9259931
doi:
Types de publication
Journal Article
Langues
eng
Pagination
878268Informations de copyright
Copyright © 2022 Stadiotti, Santoro, Scopece, Pirola, Guarino, Polvani, Maione, Ascione, Li, Delia, Foiani, Pompilio and Sommariva.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Am Heart Assoc. 2017 Jul 19;6(7):
pubmed: 28724653
Cancer Discov. 2021 Jan;11(1):80-91
pubmed: 32988960
Nat Commun. 2017 Apr 24;8:15104
pubmed: 28436431
Basic Res Cardiol. 2014;109(5):428
pubmed: 25086637
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
J Am Heart Assoc. 2017 Sep 7;6(9):
pubmed: 28882819
Circulation. 2019 Feb 26;139(9):1237-1239
pubmed: 30802166
Nature. 2019 Apr;568(7752):351-356
pubmed: 30971818
JACC Basic Transl Sci. 2019 Sep 25;4(6):670-680
pubmed: 31709317
Annu Rev Biochem. 2004;73:39-85
pubmed: 15189136
Acta Pharm Sin B. 2022 Jan;12(1):50-75
pubmed: 35127372
Prog Mol Biol Transl Sci. 2017;147:75-100
pubmed: 28413032
Annu Rev Pharmacol Toxicol. 2005;45:657-87
pubmed: 15822192
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Exp Biol Med (Maywood). 2020 Apr;245(8):748-757
pubmed: 32183553
J Mol Cell Cardiol. 2020 Apr;141:54-64
pubmed: 32205183
Nature. 2007 Mar 22;446(7134):444-8
pubmed: 17334357
Eur Heart J. 2016 Jun 14;37(23):1835-46
pubmed: 26590176
Front Physiol. 2018 Oct 23;9:1497
pubmed: 30405446
Biomed Res Int. 2014;2014:810371
pubmed: 25147815
FASEB J. 2012 May;26(5):2117-24
pubmed: 22302830
Eur Heart J. 1998 Jul;19(7):1099-108
pubmed: 9717046
J Am Coll Cardiol. 2017 Nov 14;70(20):2476-2486
pubmed: 29141781
Nat Rev Mol Cell Biol. 2006 Aug;7(8):589-600
pubmed: 16936699
Circ J. 2011;75(12):2739-48
pubmed: 22067929
J Thorac Cardiovasc Surg. 2011 Aug;142(2):285-91
pubmed: 21272899
J Cell Physiol. 2018 Dec;233(12):9099-9109
pubmed: 29943820
Cardiovasc Res. 2022 Jan 29;118(2):440-460
pubmed: 33576384
Curr Res Pharmacol Drug Discov. 2021 Feb 05;2:100017
pubmed: 34909652
Neth Heart J. 2016 Apr;24(4):275-86
pubmed: 26936157
Circ Res. 2019 Aug 2;125(4):414-430
pubmed: 31221024
Cardiovasc Drugs Ther. 2021 Apr;35(2):353-365
pubmed: 33400052
J Med Chem. 2013 Mar 14;56(5):2125-38
pubmed: 23394205
Nat Rev Cardiol. 2017 Oct;14(10):591-602
pubmed: 28492288
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Sci Transl Med. 2017 May 17;9(390):
pubmed: 28515341
Biotechnol Bioeng. 2016 Apr;113(4):859-69
pubmed: 26444553
Eur Heart J. 2021 Sep 21;42(36):3599-3726
pubmed: 34447992
J Clin Med. 2017 May 19;6(5):
pubmed: 28534817
Annu Rev Physiol. 2013;75:685-705
pubmed: 23140366
J Cell Physiol. 2019 Nov;234(11):20453-20468
pubmed: 30982981
Eur Heart J. 2021 Oct 7;42(38):3900-3901
pubmed: 34619759
Nat Rev Cardiol. 2010 Jan;7(1):30-7
pubmed: 19949426
JACC Heart Fail. 2016 Apr;4(4):312-24
pubmed: 26682792
Cardiovasc Ultrasound. 2006 Jun 27;4:25
pubmed: 16803632
Int J Mol Sci. 2021 Jul 17;22(14):
pubmed: 34299270
J Clin Invest. 2010 Jan;120(1):254-65
pubmed: 20038803
J Vis Exp. 2018 Feb 28;(132):
pubmed: 29553539
Front Cardiovasc Med. 2021 Dec 09;8:779282
pubmed: 34957261
Eur Heart J. 2019 Oct 21;40(40):3297-3317
pubmed: 31504452
Circulation. 2019 Jan 8;139(2):269-285
pubmed: 30615500