Biomarkers of Kidney Tubule Disease and Risk of End-Stage Kidney Disease in Persons With Diabetes and CKD.

biomarkers chronic kidney disease diabetes mellitus end-stage kidney disease

Journal

Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752

Informations de publication

Date de publication:
Jul 2022
Historique:
received: 21 12 2021
revised: 18 03 2022
accepted: 28 03 2022
entrez: 11 7 2022
pubmed: 12 7 2022
medline: 12 7 2022
Statut: epublish

Résumé

Tubulointerstitial damage in diabetes and chronic kidney disease (CKD) is poorly captured by estimated glomerular filtration rate (eGFR) and albuminuria. Urine biomarkers of kidney health may better elucidate disease progression in persons with diabetes and CKD. Per case-cohort design, we randomly selected a subcohort of 560 study participants of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study from 1092 adults with diabetes and baseline eGFR <60 ml/min per 1.73 m At baseline, subcohort participants had mean age of 70 ± 9 years, mean eGFR of 40 ±13 ml/min per 1.73 m Among adults with diabetes and eGFR <60 ml/min per 1.73 m

Identifiants

pubmed: 35812302
doi: 10.1016/j.ekir.2022.03.033
pii: S2468-0249(22)01253-0
pmc: PMC9263389
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1514-1523

Subventions

Organisme : NIDDK NIH HHS
ID : U01 DK085660
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK126381
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK102730
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK072381
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS041588
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK110427
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022 International Society of Nephrology. Published by Elsevier Inc.

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Auteurs

Jonathan G Amatruda (JG)

Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Kidney Health Research Collaborative, San Francisco VA Medical Center and University of California, San Francisco, San Francisco, California, USA.

Ronit Katz (R)

Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.

Mark J Sarnak (MJ)

Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Orlando M Gutierrez (OM)

Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Jason H Greenberg (JH)

Section of Nephrology, Department of Pediatrics, Clinical and Translational Research Accelerator, Yale University School of Medicine, New Haven, Connecticut, USA.

Mary Cushman (M)

Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Sushrut Waikar (S)

Section of Nephrology, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

Chirag R Parikh (CR)

Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Jeffrey R Schelling (JR)

Division of Nephrology, Department of Internal Medicine, MetroHealth System, Cleveland, Ohio, USA.
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Manasi P Jogalekar (MP)

Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Joseph V Bonventre (JV)

Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Ramachandran S Vasan (RS)

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Paul L Kimmel (PL)

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Michael G Shlipak (MG)

Kidney Health Research Collaborative, San Francisco VA Medical Center and University of California, San Francisco, San Francisco, California, USA.
Department of Medicine, San Francisco VA Health Care System, San Francisco, California, USA.

Joachim H Ix (JH)

Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California, USA.

Classifications MeSH