Incidental Findings Among Youth Participating in Multimodal Imaging Research: Characteristics of Findings and Description of a Management Approach.

bipolar disorder imaging incidental findings neuroimaging youth

Journal

Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492

Informations de publication

Date de publication:
2022
Historique:
received: 14 02 2022
accepted: 19 05 2022
entrez: 11 7 2022
pubmed: 12 7 2022
medline: 12 7 2022
Statut: epublish

Résumé

Research imaging in healthy and clinical youth populations yields incidental findings that require a management strategy. Our primary objective was to document the frequency and nature of incidental findings within a research group integrating multiple imaging modalities. A second objective was to describe the evolution of an approach to handling incidental findings. A case example was included to display the intricacies of some of these scenarios. Youth, ages 13-20 years, with bipolar disorder, familial risk for bipolar disorder, or healthy controls, obtained one or a combination of neuroimaging, cardio-thoracic imaging, retinal imaging, and carotid imaging. All images were systematically reviewed for incidental findings. Overall, of 223 participants (

Identifiants

pubmed: 35813368
doi: 10.3389/fped.2022.875934
pmc: PMC9259791
doi:

Types de publication

Journal Article

Langues

eng

Pagination

875934

Informations de copyright

Copyright © 2022 Roane, Mio, Viner, Bettridge, Heyn, Roifman, Selkirk, Kertes, MacIntosh, Thayalasuthan, Detzler, Endre, Jimenez-Juan, Henry, Murray and Goldstein.

Déclaration de conflit d'intérêts

PK declares his position on the advisory boards for Novartis, Alcon, Bayer, Novelty Nobility; Institutional financial support from Allergan, Bayer, Roche, Novartis; Personal financial support from Novartis, Bayer; and his position as an equity owner for ArcticDx. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Jessica L Roane (JL)

Sunnybrook Research Institute, Toronto, ON, Canada.
Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Megan Mio (M)

Sunnybrook Research Institute, Toronto, ON, Canada.
Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.

Jacqueline Viner (J)

Department of Classics, University of Toronto, Toronto, ON, Canada.

Ariel Bettridge (A)

Sunnybrook Research Institute, Toronto, ON, Canada.
Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Chinthaka Heyn (C)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Idan Roifman (I)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medicine, University of Toronto, Toronto, ON, Canada.
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Beth Selkirk (B)

Department of Ophthalmology & Vision Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Peter Kertes (P)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Ophthalmology & Vision Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Department of Ophthalmology & Visions Sciences, University of Toronto, Toronto, ON, Canada.

Bradley J MacIntosh (BJ)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Vivekanandan Thayalasuthan (V)

Sunnybrook Research Institute, Toronto, ON, Canada.

Garry Detzler (G)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Ruby Endre (R)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Laura Jimenez-Juan (L)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Blair Henry (B)

Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Brian J Murray (BJ)

Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Medicine, University of Toronto, Toronto, ON, Canada.
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Benjamin I Goldstein (BI)

Sunnybrook Research Institute, Toronto, ON, Canada.
Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Classifications MeSH