An
L-NAME
TGF-β1
angiotensin II
endothelial cells
endothelial functionality
endothelial-to-mesenchymal transition
reversible EndoMT
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
04
2022
accepted:
11
05
2022
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
12
7
2022
Statut:
epublish
Résumé
Endothelial cells can acquire a mesenchymal phenotype in response to external stimuli through both mechanical and biological factors, using a process known as endothelial-to-mesenchymal (EndoMT) transition. EndoMT is characterized by the decrease in endothelial characteristics, increase in mesenchymal markers, and morphological changes. It has been recognized not only during development but also in different pathological conditions including organ/tissue fibrosis in adults. The ability to modulate the EndoMT process could have a therapeutic potential in many fibrotic diseases. An
Identifiants
pubmed: 35814231
doi: 10.3389/fphar.2022.912660
pii: 912660
pmc: PMC9259860
doi:
Types de publication
Journal Article
Langues
eng
Pagination
912660Informations de copyright
Copyright © 2022 Krishnamoorthi, Thandavarayan, Youker and Bhimaraj.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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