Hypopigmented Mycosis Fungoides: A Clinicopathological Review of 32 Patients.
MF
cutaneous
hypopigmented
mycosis fungoides
Journal
Clinical, cosmetic and investigational dermatology
ISSN: 1178-7015
Titre abrégé: Clin Cosmet Investig Dermatol
Pays: New Zealand
ID NLM: 101543449
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
04
2022
accepted:
23
06
2022
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
12
7
2022
Statut:
epublish
Résumé
Hypopigmented mycosis fungoides (hMF) is gradually acknowledged by more dermatologists, yet a consensus regarding its characteristics is not reached. The profile of Chinese hMF patients has not been deeply reviewed previously. Our research may contribute to the understanding of hMF, especially the Chinese patients with Fitzpatrick phototypes of III and IV. To have a better understanding of hMF in terms of clinical, histopathological and immunohistochemical features in the Chinese population and to determine if there are differences between the Chinese population and other ethnic groups. We made a retrospective analysis of clinical, histopathological and immunohistochemical features of 32 hMF patients in our hospital from 2010 to 2020. These features were then summarized and compared with previous reports. All patients belonged to Fitzpatrick phototypes of III or IV. Twenty-one male (65.63%) patients and 11 female (34.37%) patients were analyzed, and the male to female ratio was 1.9:1. The age at diagnosis of patients ranged from 4 to 39 years, and the average age at diagnosis of these patients was 18 years, the median age was 16.5. Back was the most frequent site (34.37%). The clinical and histological results of lesions had no distinctive points. Immunohistochemically, among these 32 patients, there were 30 patients whose information was complete, there was 19 patients (63.33%) who were CD8 positive lymphocytes predominance, 9 patients (30%) had CD8 and CD4 positive lymphocyte mixed infiltration, and other 2 patients (6.67%) had CD4 positive lymphocytes predominance. Partial loss of CD7 was only observed in 1 patient (3.33%). Nearly all patients adopted topical nitrogen mustard and topical steroid and most of them had an excellent prognosis. The clinical profiles of hMF in Chinese population shared differences with other ethnic groups, but its histopathological, immunohistochemical results and prognosis condition were resembled with other previous reports. Hence, more patients were needed to find the characteristics of hMF.
Sections du résumé
Background
UNASSIGNED
Hypopigmented mycosis fungoides (hMF) is gradually acknowledged by more dermatologists, yet a consensus regarding its characteristics is not reached. The profile of Chinese hMF patients has not been deeply reviewed previously. Our research may contribute to the understanding of hMF, especially the Chinese patients with Fitzpatrick phototypes of III and IV.
Aim
UNASSIGNED
To have a better understanding of hMF in terms of clinical, histopathological and immunohistochemical features in the Chinese population and to determine if there are differences between the Chinese population and other ethnic groups.
Methods
UNASSIGNED
We made a retrospective analysis of clinical, histopathological and immunohistochemical features of 32 hMF patients in our hospital from 2010 to 2020. These features were then summarized and compared with previous reports.
Results
UNASSIGNED
All patients belonged to Fitzpatrick phototypes of III or IV. Twenty-one male (65.63%) patients and 11 female (34.37%) patients were analyzed, and the male to female ratio was 1.9:1. The age at diagnosis of patients ranged from 4 to 39 years, and the average age at diagnosis of these patients was 18 years, the median age was 16.5. Back was the most frequent site (34.37%). The clinical and histological results of lesions had no distinctive points. Immunohistochemically, among these 32 patients, there were 30 patients whose information was complete, there was 19 patients (63.33%) who were CD8 positive lymphocytes predominance, 9 patients (30%) had CD8 and CD4 positive lymphocyte mixed infiltration, and other 2 patients (6.67%) had CD4 positive lymphocytes predominance. Partial loss of CD7 was only observed in 1 patient (3.33%). Nearly all patients adopted topical nitrogen mustard and topical steroid and most of them had an excellent prognosis.
Conclusion
UNASSIGNED
The clinical profiles of hMF in Chinese population shared differences with other ethnic groups, but its histopathological, immunohistochemical results and prognosis condition were resembled with other previous reports. Hence, more patients were needed to find the characteristics of hMF.
Identifiants
pubmed: 35815242
doi: 10.2147/CCID.S370741
pii: 370741
pmc: PMC9270007
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1259-1264Informations de copyright
© 2022 Shi et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in this work.
Références
J Cutan Pathol. 2013 Nov;40(11):924-34
pubmed: 24320808
Int J Dermatol. 2018 Mar;57(3):306-312
pubmed: 29318586
Int J Dermatol. 2019 Aug;58(8):933-939
pubmed: 30761533
Australas J Dermatol. 2006 Nov;47(4):248-52
pubmed: 17034466
J Eur Acad Dermatol Venereol. 2022 May;36(5):671-679
pubmed: 35080278
Leuk Lymphoma. 2022 Jul;63(7):1598-1606
pubmed: 35201905
J Skin Cancer. 2014;2014:624143
pubmed: 25143835
Am J Surg Pathol. 2002 Apr;26(4):450-7
pubmed: 11914622
J Am Acad Dermatol. 2014 Dec;71(6):1117-26
pubmed: 25264240
J Cutan Pathol. 2013 Apr;40(4):397-404
pubmed: 23379648
Actas Dermosifiliogr (Engl Ed). 2020 Mar;111(2):149-156
pubmed: 31277835
Australas J Dermatol. 2021 Aug;62(3):e419-e420
pubmed: 33788252
Indian J Dermatol Venereol Leprol. 2011 Mar-Apr;77(2):167-73
pubmed: 21393946
J Eur Acad Dermatol Venereol. 2017 May;31(5):808-814
pubmed: 27515575
J Cutan Pathol. 2021 Apr;48(4):486-494
pubmed: 32965737