Biomarkers in Heart Failure with Preserved Ejection Fraction.
Heart failure with preserved ejection fraction
fibrosis
insulin-like growth factor-binding protein-7
interleukin-1 receptorlike 1
natriuretic peptides
troponin
Journal
Cardiac failure review
ISSN: 2057-7540
Titre abrégé: Card Fail Rev
Pays: England
ID NLM: 101696210
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
22
12
2021
accepted:
02
03
2022
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
12
7
2022
Statut:
epublish
Résumé
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder developing from multiple aetiologies with overlapping pathophysiological mechanisms. HFpEF diagnosis may be challenging, as neither cardiac imaging nor physical examination are sensitive in this situation. Here, we review biomarkers of HFpEF, of which the best supported are related to myocardial stretch and injury, including natriuretic peptides and cardiac troponins. An overview of biomarkers of inflammation, extracellular matrix derangements and fibrosis, senescence, vascular dysfunction, anaemia/iron deficiency and obesity is also provided. Finally, novel biomarkers from -omics technologies, including plasma metabolites and circulating microRNAs, are outlined briefly. A cardiac-centred approach to HFpEF diagnosis using natriuretic peptides seems reasonable at present in clinical practice. A holistic approach including biomarkers that provide information on the non-cardiac components of the HFpEF syndrome may enrich our understanding of the disease and may be useful in classifying HFpEF phenotypes or endotypes that may guide patient selection in HFpEF trials.
Identifiants
pubmed: 35815256
doi: 10.15420/cfr.2021.37
pmc: PMC9253965
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e20Informations de copyright
Copyright © 2022, Radcliffe Cardiology.
Déclaration de conflit d'intérêts
Disclosure: AB-G has received speaker fees or participated on boards from Abbott, AstraZeneca, Boehringer Ingelheim, Roche Diagnostics, Critical Diagnostics, Vifor and Novartis. All other authors have no conflicts of interest to declare.
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