Seeking heterocyclic scaffolds as antivirals against dengue virus.

Aedes Animals Antiviral Agents / pharmacology Dengue Virus Female Humans Nitrogen Oxygen
Antiviral medication Dengue virus Heterocyclic scaffolds Neglected tropical diseases Structure-activity relationship Surface activity

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Oct 2022
Historique:
received: 27 04 2022
revised: 24 06 2022
accepted: 25 06 2022
pubmed: 12 7 2022
medline: 17 8 2022
entrez: 11 7 2022
Statut: ppublish

Résumé

Dengue is one of the most typical viral infection categorized in the Neglected Tropical Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and majorly puts risk to the lives of more than half of the world. Recent advancements in medicinal chemistry have led to the design and development of numerous potential heterocyclic scaffolds as antiviral drug candidates for the inhibition of the dengue virus (DENV). Thus, in this review, we have discussed the significance of inhibitory and antiviral activities of nitrogen, oxygen, and mixed (nitrogen-sulfur and nitrogen-oxygen) heterocyclic scaffolds that are published in the last seven years (2016-2022). Furthermore, we have also discussed the probable mechanisms of action and the diverse structure-activity relationships (SARs) of the heterocyclic scaffolds. In addition, this review has elaborately outlined the mechanism of viral infection and the life cycle of DENV in the host cells. The wide set of heterocycles and their SARs will aid in the development of pharmaceuticals that will allow the researchers to synthesize the promising anti-dengue drug candidate in the future.

Identifiants

DOI: 10.1016/j.ejmech.2022.114576 PMID: 35816877 PMC: PMC9250831
pubmed: 35816877
pii: S0223-5234(22)00478-0
doi: 10.1016/j.ejmech.2022.114576
pmc: PMC9250831
pii:
doi:

Substances chimiques

Antiviral Agents 0
Nitrogen N762921K75
Oxygen S88TT14065

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114576

Informations de copyright

Copyright © 2022 Elsevier Masson SAS. All rights reserved.

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Auteurs

Soumik De (S)

Department of Chemistry, National Institute of Technology, Silchar, Assam, 788010, India.

Bari Aamna (B)

School of Biotechnology, Kalinga Institute of Industrial Technology (Deemed to be University), Bhubaneswar, Odisha, 751024, India.

Raghaba Sahu (R)

College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address: raghabasahu@gmail.com.

Sagarika Parida (S)

Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, 752050, India. Electronic address: sagarika.parida@cutm.ac.in.

Santosh Kumar Behera (SK)

Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Palaj, Gandhinagar, Gujarat, 382355, India. Electronic address: bioinfo.santosh@gmail.com.

Aritra Kumar Dan (AK)

School of Biotechnology, Kalinga Institute of Industrial Technology (Deemed to be University), Bhubaneswar, Odisha, 751024, India. Electronic address: aritradan34@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › Aedes › Seeking heterocyclic scaffolds as antivirals...
questionsmedicales.fr › Eucaryotes › Animaux › Seeking heterocyclic scaffolds as antivirals...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Seeking heterocyclic scaffolds as antivirals...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus de la dengue › Seeking heterocyclic scaffolds as antivirals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Seeking heterocyclic scaffolds as antivirals...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Azote › Seeking heterocyclic scaffolds as antivirals...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Seeking heterocyclic scaffolds as antivirals...