Histopathological Landscape of Precursor Lesions of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms.

Humans Pancreatic Neoplasms / pathology Neuroendocrine Tumors / pathology Pancreas / pathology Stomach Neoplasms / pathology Intestinal Neoplasms / pathology
Dysplasia Gastro-entero-pancreatic tract Hyperplasia Neuroendocrine neoplasm Preneoplastic lesions

Journal

Digestive diseases (Basel, Switzerland)
ISSN: 1421-9875
Titre abrégé: Dig Dis
Pays: Switzerland
ID NLM: 8701186

Informations de publication

Date de publication:
2023
Historique:
received: 19 12 2021
accepted: 12 05 2022
pubmed: 12 7 2022
medline: 26 1 2023
entrez: 11 7 2022
Statut: ppublish

Résumé

Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known. This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure. The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases.

Sections du résumé

BACKGROUND BACKGROUND
Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known.
SUMMARY CONCLUSIONS
This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure.
KEY MESSAGES CONCLUSIONS
The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases.

Identifiants

DOI: 10.1159/000525421 PMID: 35816999
pubmed: 35816999
pii: 000525421
doi: 10.1159/000525421
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-48

Informations de copyright

© 2022 S. Karger AG, Basel.

Auteurs

Rachele Biancotti (R)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Carlo Alberto Dal Pozzo (CA)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Paola Parente (P)

Pathology Unit, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Gianluca Businello (G)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Valentina Angerilli (V)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Stefano Realdon (S)

Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.

Edoardo Vincenzo Savarino (EV)

Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Fabio Farinati (F)

Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Anna Caterina Milanetto (AC)

Division of Surgery, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Claudio Pasquali (C)

Division of Surgery, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Roberto Vettor (R)

Endocrine-Metabolic Laboratory, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Center for the Study and the Integrated Management of Obesity, Padua University Hospital, Padua, Italy.

Federica Grillo (F)

Anatomic Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DICS), University of Genova, Genova, Italy.
Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genova, Italy.

Gianmaria Pennelli (G)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Claudio Luchini (C)

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.

Luca Mastracci (L)

Anatomic Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DICS), University of Genova, Genova, Italy.
Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genova, Italy.

Alessandro Vanoli (A)

Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.

Massimo Milione (M)

1st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Francesca Galuppini (F)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Matteo Fassan (M)

Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Histopathological Landscape of Precursor...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Histopathological Landscape of Precursor...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Histopathological Landscape of Precursor...
questionsmedicales.fr › Système digestif › Pancréas › Histopathological Landscape of Precursor...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Histopathological Landscape of Precursor...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Histopathological Landscape of Precursor...