Toll-like receptor-1, -2, and -6 genotypes in relation to salivary human beta-defensin-1, -2, -3 and human neutrophilic peptide-1.
defensins
genetic
periodontium
polymorphism
saliva
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
07
06
2022
received:
28
01
2022
accepted:
06
07
2022
pubmed:
12
7
2022
medline:
19
10
2022
entrez:
11
7
2022
Statut:
ppublish
Résumé
To examine whether functional gene polymorphisms of toll-like receptor (TLR)1, TLR2, and TLR6 are related to the salivary concentrations of human beta-defensins (hBDs)-1, -2, -3, and human neutrophilic peptide (HNP)-1. Polymorphisms of TLR1 (rs5743618), TLR2 (rs5743708), and TLR6 (rs5743810) were genotyped by PCR-based pyrosequencing from the salivary samples of 230 adults. Salivary hBD-1, -2, -3, and HNP-1 concentrations were measured using enzyme-linked immunosorbent assay. General and periodontal health examinations, including panoramic radiography, were available for all participants. The genotype frequencies for wild types and variant types were as follows: 66.5% and 33.5% for TLR1, 95.5% and 4.5% for TLR2, and 25.1% and 74.9% for TLR6, respectively. The TLR2 heterozygote variant group exhibited higher salivary hBD-2 concentrations than the TLR2 wild-type group (p = .038). On the contrary, elevated hBD-2 concentrations were detected in the TLR6 wild-type group compared with the TLR6 heterozygote and homozygote variant group (p = .028). The associations between TLR6 genotypes and salivary hBD-2 concentrations remained significant after adjusting them for periodontal status, age, and smoking. hBD-2 concentrations in saliva are related to TLR2 and TLR6 polymorphisms, but only the TLR6 genotype seems to exhibit an independent association with the salivary hBD-2 concentrations.
Identifiants
pubmed: 35817420
doi: 10.1111/jcpe.13697
pmc: PMC9796255
doi:
Substances chimiques
Toll-Like Receptor 1
0
Toll-Like Receptor 2
0
Toll-Like Receptor 6
0
alpha-Defensins
0
beta-Defensins
0
human neutrophil peptide 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1185-1191Subventions
Organisme : Academy of Finland
Organisme : Suomen Hammaslääkäriseura Apollonia
Informations de copyright
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
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