Kidney Disease Following Hematopoietic Stem Cell Transplantation.
Acute kidney injury
Allogeneic stem cell transplant
Chronic kidney disease
Hepatic sinusoidal obstruction
Thrombotic microangiopathy
Journal
Advances in chronic kidney disease
ISSN: 1548-5609
Titre abrégé: Adv Chronic Kidney Dis
Pays: United States
ID NLM: 101209214
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
24
06
2021
revised:
07
10
2021
accepted:
15
11
2021
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
14
7
2022
Statut:
ppublish
Résumé
Hematopoietic stem cell transplantation (SCT) provides a curative option for the treatment of several malignancies. Its growing use is associated with an increased burden of kidney disease. Acute kidney injury is usually seen within the first 100 days of transplantation and has an incidence ranging between 12 and 73%, with the highest rate in myeloablative allogeneic SCT. A large subset of patients after SCT develop chronic kidney disease. They can be broadly classified into thrombotic microangiopathy, nephrotic syndrome, and calcineurin toxicity. Dialysis requirement after SCT is associated with mortality exceeding 80%. Given the higher morbidity and mortality related to development kidney disease, nephrologists need to be aware of the various causes and best treatment options.
Identifiants
pubmed: 35817518
pii: S1548-5595(21)00145-2
doi: 10.1053/j.ackd.2021.11.003
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-115.e1Informations de copyright
Copyright © 2021 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.