Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome.
Acute lung injury
COVID-19
Electrical impedance tomography
Multiple inert gas elimination technique
Recruitment-on-inflation ratio
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
11 07 2022
11 07 2022
Historique:
received:
09
01
2022
accepted:
05
07
2022
entrez:
11
7
2022
pubmed:
12
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
In the acute respiratory distress syndrome (ARDS), decreasing Ventilation-Perfusion [Formula: see text] mismatch might enhance lung protection. We investigated the regional effects of higher Positive End Expiratory Pressure (PEEP) on [Formula: see text] mismatch and their correlation with recruitability. We aimed to verify whether PEEP improves regional [Formula: see text] mismatch, and to study the underlying mechanisms. In fifteen patients with moderate and severe ARDS, two PEEP levels (5 and 15 cmH In the non-dependent region, at higher PEEP, ventilation reaching the normal [Formula: see text] compartment (p = 0.018) increased, while it decreased in the high [Formula: see text] one (p = 0.023). In the middle region, at PEEP 15 cmH In patients with ARDS, higher PEEP optimizes the distribution of both ventilation (in the non-dependent areas) and perfusion (in the middle and dependent lung). Bedside measure of recruitability is associated with improved [Formula: see text] mismatch.
Identifiants
pubmed: 35818077
doi: 10.1186/s13054-022-04085-y
pii: 10.1186/s13054-022-04085-y
pmc: PMC9272883
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
211Informations de copyright
© 2022. The Author(s).
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