The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach.
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
07
04
2022
accepted:
07
07
2022
pubmed:
13
7
2022
medline:
19
10
2022
entrez:
12
7
2022
Statut:
ppublish
Résumé
The post-acute COVID-19 syndrome (PACS) is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase. Current data suggests that at least 10% of people with previously documented infection may develop PACS, and up to 50-80% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory.
Identifiants
pubmed: 35820609
pii: S1568-1637(22)00128-3
doi: 10.1016/j.arr.2022.101686
pmc: PMC9270773
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101686Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Conflict of interest GG and CM received research grant and speaker honorarium from Gilead, ViiV, MERCK and Jansen. GG and CM attended advisory boards of Gilead, ViiV and MERCK. Other authors did not report conflicts of interest.
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