The role of gut microbial β-glucuronidase in drug disposition and development.
Drug development
Drug disposition
Druggable target
Gut microbial β-glucuronidase
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
05
04
2022
revised:
27
05
2022
accepted:
05
07
2022
pubmed:
13
7
2022
medline:
5
10
2022
entrez:
12
7
2022
Statut:
ppublish
Résumé
Gut microbial β-glucuronidase (gmGUS) is involved in the disposition of many endogenous and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity affects drug disposition, resulting in reduced toxicity in the gastrointestinal tract (GIT) and enhanced systemic efficacy. Additionally, manipulating gmGUS activity is expected to be effective in preventing/treating local or systemic diseases. Although results from animal studies are promising, challenges remain in developing drugs by targeting gmGUS. Here, we review the role of gmGUS in host health under physiological and pathological conditions, the impact of gmGUS on the disposition of phenolic compounds, models used to study gmGUS activity, and the perspectives and challenges in developing drugs by targeting gmGUS.
Identifiants
pubmed: 35820618
pii: S1359-6446(22)00286-0
doi: 10.1016/j.drudis.2022.07.001
pmc: PMC9717552
mid: NIHMS1853665
pii:
doi:
Substances chimiques
Glucuronidase
EC 3.2.1.31
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103316Subventions
Organisme : NCI NIH HHS
ID : R01 CA246209
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM070737
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM135813
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM142421
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Références
Sci Rep. 2018 Feb 26;8(1):3596
pubmed: 29483538
Toxicol Sci. 2013 Feb;131(2):654-67
pubmed: 23091168
Ann Oncol. 2021 Sep;32(9):1157-1166
pubmed: 34129855
Arztl Jugendkd. 1990;81(1):2-3
pubmed: 2356777
Rev Infect Dis. 1984 Mar-Apr;6 Suppl 1:S85-90
pubmed: 6326245
J Med Microbiol. 1998 May;47(5):407-16
pubmed: 9879941
Front Biosci (Landmark Ed). 2017 Jan 1;22(4):669-691
pubmed: 27814639
Structure. 2017 Jul 5;25(7):967-977.e5
pubmed: 28578872
Clin Obes. 2021 Feb;11(1):e12423
pubmed: 33135396
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7374-7381
pubmed: 32170007
Cancer Chemother Pharmacol. 2011 Jan;67(1):201-13
pubmed: 20354702
Breast Cancer Res Treat. 2020 Jan;179(2):287-300
pubmed: 31646389
Rejuvenation Res. 2013 Oct;16(5):352-63
pubmed: 23777470
Drug Metab Dispos. 1999 Sep;27(9):1064-7
pubmed: 10460807
Sci Rep. 2019 Jan 29;9(1):825
pubmed: 30696850
Ther Adv Urol. 2015 Dec;7(6):378-87
pubmed: 26622322
Therap Adv Gastroenterol. 2015 Jul;8(4):206-20
pubmed: 26136838
PLoS One. 2016 Jan 29;11(1):e0148291
pubmed: 26824357
Arch Pharm Res. 2000 Apr;23(2):172-7
pubmed: 10836746
Chem Biol. 2015 Sep 17;22(9):1238-49
pubmed: 26364932
Food Funct. 2021 Nov 15;12(22):11190-11201
pubmed: 34668903
Prog Clin Biol Res. 1990;328:477-80
pubmed: 2154808
J Biol Chem. 1958 Oct;233(4):872-85
pubmed: 13587508
Food Chem Toxicol. 2017 Nov;109(Pt 2):975-983
pubmed: 28347758
Front Microbiol. 2021 Feb 25;12:584332
pubmed: 33716996
SLAS Discov. 2018 Jan;23(1):76-83
pubmed: 28809607
Ann Oncol. 2009 Mar;20(3):574-80
pubmed: 18765463
Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1288-95
pubmed: 23064760
Bioinformatics. 2012 Apr 15;28(8):1166-7
pubmed: 22368248
ACS Sens. 2019 Sep 27;4(9):2553
pubmed: 31436411
Pharmaceutics. 2021 Jul 08;13(7):
pubmed: 34371734
J Biotechnol. 2006 Nov 1;126(2):135-9
pubmed: 16730833
Cancer Chemother Pharmacol. 2016 May;77(5):1039-52
pubmed: 27053087
ACS Cent Sci. 2018 Jul 25;4(7):868-879
pubmed: 30062115
Curr Drug Targets. 2013 Jun;14(7):777-97
pubmed: 23597015
Sci Adv. 2019 Aug 07;5(8):eaax2358
pubmed: 31457102
J Appl Bacteriol. 1993 Mar;74(3):223-33
pubmed: 8468256
Carcinogenesis. 2011 Sep;32(9):1366-71
pubmed: 21734256
Colorectal Dis. 2005 Jan;7(1):27-34
pubmed: 15606581
J Biol Chem. 2018 Nov 30;293(48):18559-18573
pubmed: 30301767
J Pharmacol Exp Ther. 2003 Mar;304(3):1228-35
pubmed: 12604700
J Microbiol Methods. 2002 Mar;49(1):31-54
pubmed: 11777581
Analyst. 2015 Sep 7;140(17):5953-64
pubmed: 26225370
Science. 2010 Nov 5;330(6005):831-5
pubmed: 21051639
Pediatr Blood Cancer. 2010 Jul 1;54(7):909-15
pubmed: 20405511
Appl Environ Microbiol. 1982 Jun;43(6):1320-9
pubmed: 7049088
Cell Res. 2017 Jun;27(6):784-800
pubmed: 28409562
J Urol. 2021 May;205(5):1361-1371
pubmed: 33356529
Cells. 2019 Dec 15;8(12):
pubmed: 31847455
J Biol Chem. 2019 Dec 6;294(49):18586-18599
pubmed: 31636122
ACS Chem Biol. 2019 Dec 20;14(12):2737-2744
pubmed: 31663730
Sci Rep. 2018 May 25;8(1):8166
pubmed: 29802368
PLoS One. 2021 Jan 7;16(1):e0244876
pubmed: 33411719
J Microbiol Biotechnol. 2012 Jun;22(6):838-48
pubmed: 22573163
Nutr Cancer. 1982;4(2):120-7
pubmed: 6298751
J Steroid Biochem. 1987;27(4-6):1145-9
pubmed: 3320550
Nat Commun. 2022 Jan 10;13(1):136
pubmed: 35013263
Protein Sci. 2018 Dec;27(12):2010-2022
pubmed: 30230652
Science. 1974 Feb 1;183(4123):416-7
pubmed: 4808971
J Chromatogr B Biomed Sci Appl. 2001 Oct 5;762(1):33-41
pubmed: 11589456
BMC Microbiol. 2019 May 16;19(1):99
pubmed: 31096909
Transpl Infect Dis. 2007 Dec;9(4):270-5
pubmed: 17511817
Pol J Microbiol. 2013;62(3):319-25
pubmed: 24459840
J Biol Chem. 2017 May 26;292(21):8569-8576
pubmed: 28389557
Exp Mol Pathol. 2015 Jun;98(3):375-81
pubmed: 25445497
Transplantation. 2003 Mar 15;75(5):665-72
pubmed: 12640307
Cancer Res. 2004 Mar 1;64(5):1579-83
pubmed: 14996712
Am J Physiol Gastrointest Liver Physiol. 2020 Apr 1;318(4):G816-G826
pubmed: 32146834
Appl Microbiol Biotechnol. 2018 Apr;102(7):3017-3026
pubmed: 29476402
Biotechnol Lett. 2007 Apr;29(4):531-7
pubmed: 17235488
Phytother Res. 2022 May;36(5):1854-1883
pubmed: 35102626
Front Cell Dev Biol. 2021 Aug 12;9:631552
pubmed: 34458248
Front Endocrinol (Lausanne). 2019 Jul 31;10:504
pubmed: 31417492
Pharmacol Rep. 2021 Dec;73(6):1497-1512
pubmed: 34462889
Gastroenterology. 1992 May;102(5):1475-82
pubmed: 1314747
Am J Transl Res. 2020 Nov 15;12(11):7459-7474
pubmed: 33312382
Br J Pharmacol. 2006 Jan;147 Suppl 1:S82-8
pubmed: 16402124
Pharmacol Res. 2019 Jan;139:41-49
pubmed: 30391354
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E152-E161
pubmed: 29269393
Clin Cancer Res. 2014 Jul 1;20(13):3521-30
pubmed: 24780296
J Anal Toxicol. 1995 May-Jun;19(3):157-62
pubmed: 7564293
N Engl J Med. 1982 Dec 16;307(25):1542-7
pubmed: 7144835
Mini Rev Med Chem. 2010 Jun;10(6):550-67
pubmed: 20370701
J Opioid Manag. 2005 Jul-Aug;1(3):153-61
pubmed: 17315419
Biochem Pharmacol. 2021 Aug;190:114566
pubmed: 33865833
ACS Sens. 2018 Sep 28;3(9):1727-1734
pubmed: 30149692
Environ Microbiol. 2012 Aug;14(8):1876-87
pubmed: 22364273
Gynecol Endocrinol. 2017 Feb;33(2):87-92
pubmed: 27898258
J Med Chem. 2017 Nov 22;60(22):9222-9238
pubmed: 29120626
Toxicol Appl Pharmacol. 2020 Jul 1;398:115032
pubmed: 32387182
Xenobiotica. 2014 Jan;44(1):28-35
pubmed: 23829165
Prog Brain Res. 1983;58:11-20
pubmed: 6138807
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4539-46
pubmed: 20615998
Biomedicines. 2022 Feb 13;10(2):
pubmed: 35203645