A trustworthy mechanochemical route to isocyanides.
green chemistry
isocyanide
isonitriles
mechanochemistry
Journal
Beilstein journal of organic chemistry
ISSN: 1860-5397
Titre abrégé: Beilstein J Org Chem
Pays: Germany
ID NLM: 101250746
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
04
2022
accepted:
10
06
2022
entrez:
13
7
2022
pubmed:
14
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Isocyanides are hardly produced, dramatically sensitive to purification processes, and complex to handle as synthetic tools. Notwithstanding, they represent one of the most refined and valuable compounds for accessing sophisticated and elegant synthetic routes. A unique interest has always been addressed to their production, though their synthetic pathways usually involve employing strong conditions and toxic reagents. The current paper intends to provide a conceptually innovative synthetic protocol for mechanochemical isocyanide preparation, simultaneously lowering the related reagents' toxicity and improving their purification in a straightforward procedure.
Identifiants
pubmed: 35821692
doi: 10.3762/bjoc.18.73
pmc: PMC9235834
doi:
Types de publication
Journal Article
Langues
eng
Pagination
732-737Informations de copyright
Copyright © 2022, Basoccu et al.
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