A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage.
cardiometabolic diseases
glutathione
glycine
healthy aging
n-acetylcysteine
nutrition
oxidative stress
total cysteine
Journal
Frontiers in aging
ISSN: 2673-6217
Titre abrégé: Front Aging
Pays: Switzerland
ID NLM: 9918231199706676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
01
2022
accepted:
08
02
2022
entrez:
13
7
2022
pubmed:
14
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Glycine and cysteine are non-essential amino acids that are required to generate glutathione, an intracellular tripeptide that neutralizes reactive oxygen species and prevents tissue damage. During aging glutathione demand is thought to increase, but whether additional dietary intake of glycine and cysteine contributes towards the generation of glutathione in healthy older adults is not well understood. We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (low dose: 2.4 g, medium dose: 4.8 g, or high dose: 7.2 g/day, 1:1 ratio) in a randomized, controlled clinical trial in 114 healthy volunteers. Despite representing a cohort of healthy older adults (age mean = 65 years), we found significantly higher baseline levels of markers of oxidative stress, including that of malondialdehyde (MDA, 0.158
Identifiants
pubmed: 35821844
doi: 10.3389/fragi.2022.852569
pii: 852569
pmc: PMC9261343
doi:
Banques de données
ClinicalTrials.gov
['NCT05041179']
Types de publication
Journal Article
Langues
eng
Pagination
852569Informations de copyright
Copyright © 2022 Lizzo, Migliavacca, Lamers, Frézal, Corthesy, Vinyes-Parès, Bosco, Karagounis, Hövelmann, Heise, von Eynatten and Gut.
Déclaration de conflit d'intérêts
GL, EM, AF, JC, NB, and PG are employees of Nestlé Institute of Health Sciences, Nestlé Research, Societé des Produits de Nestlé. GV-P, LK, and ME are employees of Nestlé Health Sciences, a subsidiary of Nestlé. Nestlé Health Sciences holds patents and licenses to patents and markets products for the use of glycine and n-acetylcysteine in conditions related to impaired mitochondrial functions. DL and UH are employees and TH is an employee and shareholder of Profil Institute for Metabolic Research GmbH, which has received research funding from Nestlé Health Sciences.
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