Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity.
aging
anti-inflammation
chronic inflammation
immune system
immunosenecence
inflammaging
obesity
Journal
Frontiers in aging
ISSN: 2673-6217
Titre abrégé: Front Aging
Pays: Switzerland
ID NLM: 9918231199706676
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
06
2021
accepted:
25
08
2021
entrez:
13
7
2022
pubmed:
14
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Aging and obesity are two conditions characterized by chronic, low-grade inflammation. While both conditions are also associated with dysfunctional immune responses, the shared and distinct underlying mechanisms are just starting to be uncovered. In fact, recent findings have suggested that the effects of obesity on the immune system can be thought of as a state of accelerated aging. Here we propose that chronic, low-grade inflammation seen in obesity and aging is complex, affects multiple cell types, and results in an altered basal immune state. In aging, part of this altered state is the emergence of regulatory immune populations that lead to further immune dysfunction in an attempt to reduce chronic inflammation. While in obesity, part of the altered state is the effect of expanding adipose tissue on immune cell function. Thus, in this review, we compare, and contrast altered immune states in aging and obesity and discuss their potential contribution to a shared clinical problem- decreased vaccine responsiveness.
Identifiants
pubmed: 35822048
doi: 10.3389/fragi.2021.732414
pii: 732414
pmc: PMC9261339
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
732414Subventions
Organisme : NIA NIH HHS
ID : R01 AG033057
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053498
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG065327
Pays : United States
Informations de copyright
Copyright © 2021 Thomas, Alarcon, Divanovic, Chougnet, Hildeman and Moreno-Fernandez.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Immun Ageing. 2018 Jan 19;15:1
pubmed: 29387133
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8
pubmed: 23479618
Nature. 2020 Mar;579(7800):581-585
pubmed: 32103173
Nat Med. 2011 May;17(5):610-7
pubmed: 21499269
Front Immunol. 2019 Aug 08;10:1874
pubmed: 31440251
Front Immunol. 2017 Dec 07;8:1745
pubmed: 29270179
Exp Gerontol. 1999 Dec;34(8):959-70
pubmed: 10673149
PLoS One. 2020 Apr 2;15(4):e0230885
pubmed: 32240221
Vaccine. 1997 Jul;15(10):1157-61
pubmed: 9269062
Exp Mol Med. 2009 Mar 31;41(3):208-16
pubmed: 19293640
Immunology. 2018 Dec;155(4):407-417
pubmed: 30229891
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20012-7
pubmed: 22123971
J Immunol. 2017 Aug 1;199(3):1060-1068
pubmed: 28646038
Obesity (Silver Spring). 2015 Mar;23(3):512-8
pubmed: 25612251
Nat Commun. 2021 May 18;12(1):2911
pubmed: 34006859
Nat Med. 2009 Aug;15(8):930-9
pubmed: 19633656
Int J Mol Med. 2008 Feb;21(2):233-8
pubmed: 18204790
J Clin Endocrinol Metab. 2007 Mar;92(3):1023-33
pubmed: 17164304
Mech Ageing Dev. 2017 Jul;165(Pt B):129-138
pubmed: 28038993
Am J Pathol. 2011 Jul;179(1):199-210
pubmed: 21703402
Clin Exp Immunol. 2015 Jan;179(1):90-9
pubmed: 25169121
Oncotarget. 2016 Jun 7;7(23):33581-94
pubmed: 27177221
Vaccine. 2010 Nov 29;28(51):8077-84
pubmed: 20974306
JAMA. 1985 Dec 13;254(22):3187-9
pubmed: 2933532
Nutr Diabetes. 2021 Jun 7;11(1):15
pubmed: 34099626
Ageing Res Rev. 2015 Nov;24(Pt A):3-16
pubmed: 25446804
Nat Rev Endocrinol. 2017 Nov;13(11):633-643
pubmed: 28799554
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26
pubmed: 26658771
Vaccine. 2003 Sep 8;21(25-26):3623-8
pubmed: 12922091
JCI Insight. 2021 Apr 22;6(8):
pubmed: 33724954
Cell Metab. 2013 Nov 5;18(5):759-766
pubmed: 24209772
J Immunol. 2014 Jan 15;192(2):623-9
pubmed: 24323581
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5306-11
pubmed: 19279209
Biochem Biophys Res Commun. 2009 Jul 10;384(4):482-5
pubmed: 19422792
Sci Adv. 2020 Jul 29;6(31):eabb0806
pubmed: 32832688
Vaccine. 2014 Feb 12;32(8):979-83
pubmed: 24394442
Life Sci. 1992;51(25):1953-6
pubmed: 1453878
J Immunol. 2006 Dec 15;177(12):8348-55
pubmed: 17142731
Sci Rep. 2019 Aug 22;9(1):12284
pubmed: 31439906
J Immunol. 2012 Aug 1;189(3):1311-21
pubmed: 22745381
Cell Metab. 2021 Jun 1;33(6):1187-1204.e9
pubmed: 34004162
J Lipid Res. 2008 Sep;49(9):1894-903
pubmed: 18503031
Pflugers Arch. 2017 Apr;469(3-4):385-396
pubmed: 28233125
Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2312-8
pubmed: 18818415
Annu Rev Immunol. 2011;29:415-45
pubmed: 21219177
J Clin Invest. 2008 Sep;118(9):2992-3002
pubmed: 18769626
Sci Rep. 2016 Apr 25;6:25051
pubmed: 27109638
Cell Immunol. 2018 Oct;332:1-6
pubmed: 30146083
J Interferon Cytokine Res. 2019 Aug;39(8):459-471
pubmed: 30920343
Clin Exp Pharmacol Physiol. 2017 May;44(5):556-565
pubmed: 28222218
Mech Ageing Dev. 2017 Mar;162:91-99
pubmed: 28111127
Int Immunol. 2000 May;12(5):597-605
pubmed: 10784605
Nat Med. 2009 Aug;15(8):914-20
pubmed: 19633658
J Neuroinflammation. 2008 Nov 11;5:51
pubmed: 19014446
Nutr Diabetes. 2013 Mar 18;3:e64
pubmed: 23507968
Vaccine. 2015 Aug 26;33(36):4422-9
pubmed: 26163925
Proc Nutr Soc. 2012 May;71(2):332-8
pubmed: 22429824
Front Immunol. 2020 May 27;11:860
pubmed: 32528467
Sci Rep. 2019 Oct 11;9(1):14678
pubmed: 31604985
J Clin Immunol. 2011 Jun;31(3):430-5
pubmed: 21318330
Aging Cell. 2012 Jun;11(3):509-19
pubmed: 22372596
Nat Rev Immunol. 2008 Jul;8(7):512-22
pubmed: 18469829
J Diabetes Sci Technol. 2011 Mar 01;5(2):426-32
pubmed: 21527115
Obesity (Silver Spring). 2013 Mar;21(3):461-8
pubmed: 23592653
Exp Physiol. 2017 May 1;102(5):533-544
pubmed: 28205317
Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S406-S409
pubmed: 29161078
Nature. 2014 May 22;509(7501):439-46
pubmed: 24848057
Exp Gerontol. 2001 Mar;36(3):547-57
pubmed: 11250125
Sci Rep. 2019 Jul 23;9(1):10680
pubmed: 31337827
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
J Immunol. 2015 Aug 1;195(3):944-52
pubmed: 26109645
Circ Res. 2012 Apr 13;110(8):1097-108
pubmed: 22499900
Mech Ageing Dev. 2007 Nov-Dec;128(11-12):672-80
pubmed: 18036633
Semin Immunol. 2012 Oct;24(5):356-64
pubmed: 22554418
J Immunol. 2015 Jun 15;194(12):5825-37
pubmed: 25957168
Aging Cell. 2014 Jun;13(3):441-8
pubmed: 24325345
J Immunol. 2015 Sep 15;195(6):2624-32
pubmed: 26246142
Obesity (Silver Spring). 2016 Mar;24(3):615-25
pubmed: 26857091
PLoS One. 2014 Mar 04;9(3):e90639
pubmed: 24595332
Crit Care. 2011 Apr 20;15(2):221
pubmed: 21586104
J Clin Invest. 2016 Dec 1;126(12):4626-4639
pubmed: 27820698
J Exp Med. 2020 Aug 3;217(8):
pubmed: 32478834
J Virol. 2001 Dec;75(24):12182-7
pubmed: 11711609
Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1559-63
pubmed: 8108444
Exp Gerontol. 2018 Feb;102:101-108
pubmed: 29221940
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
J Immunol. 2006 Jun 1;176(11):6586-93
pubmed: 16709816
Influenza Other Respir Viruses. 2010 Sep;4(5):307-11
pubmed: 20716159
J Immunol. 2015 Jun 1;194(11):5253-60
pubmed: 25917102
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9765-70
pubmed: 20445103
Hum Immunol. 2015 Sep;76(9):622-30
pubmed: 26386144
Obesity (Silver Spring). 2012 Jul;20(7):1372-8
pubmed: 22395812
Infect Immun. 2008 Nov;76(11):5191-9
pubmed: 18765736
Cell Metab. 2020 Jul 7;32(1):44-55.e6
pubmed: 32402267
J Leukoc Biol. 2000 Jan;67(1):40-5
pubmed: 10647996
J Biol Chem. 2011 Jul 1;286(26):23591-9
pubmed: 21592961
Nat Med. 2019 Mar;25(3):487-495
pubmed: 30842675
Exp Clin Endocrinol Diabetes. 2018 Feb;126(2):96-101
pubmed: 28954308
Aging Cell. 2014 Aug;13(4):699-708
pubmed: 24813244
Ageing Res Rev. 2011 Jul;10(3):330-5
pubmed: 20728581
Vaccine. 2000 Feb 25;18(16):1717-20
pubmed: 10689155
Diabetes. 2009 Nov;58(11):2525-35
pubmed: 19690064
Cell Physiol Biochem. 2016;38(3):1257-66
pubmed: 26982979
Aging Dis. 2019 Feb 01;10(1):49-61
pubmed: 30705767
J Immunol. 2008 Aug 1;181(3):1835-48
pubmed: 18641321
Immunol Lett. 2019 Mar;207:56-63
pubmed: 30658078
Hum Vaccin Immunother. 2018;14(8):1853-1866
pubmed: 29517396
Mol Med Rep. 2015 Mar;11(3):2322-8
pubmed: 25384365
N Engl J Med. 2007 Oct 4;357(14):1373-81
pubmed: 17914038
Nat Commun. 2020 Jun 2;11(1):2745
pubmed: 32488081
Diabetes. 2011 Nov;60(11):2954-62
pubmed: 21911743
Nat Immunol. 2015 Apr;16(4):376-85
pubmed: 25729921
Diabetes. 2012 Sep;61(9):2238-47
pubmed: 22596049
Eur J Immunol. 2016 Nov;46(11):2650-2658
pubmed: 27546296
Diabetes. 2007 Dec;56(12):2910-8
pubmed: 17848624
PLoS One. 2016 Aug 02;11(8):e0160407
pubmed: 27483441
Mucosal Immunol. 2021 Nov;14(6):1224-1234
pubmed: 33958704
Obes Surg. 2018 Jun;28(6):1611-1621
pubmed: 29238916
Sci Rep. 2018 Oct 12;8(1):15203
pubmed: 30315279
Nat Med. 2012 Sep;18(9):1407-12
pubmed: 22863787
Vaccine. 2015 Jun 26;33(29):3306-13
pubmed: 26044491
Clin Immunol. 2017 Apr;177:12-17
pubmed: 26794911
Curr Opin Immunol. 2012 Aug;24(4):482-7
pubmed: 22560294
Immun Ageing. 2020 Nov 19;17(1):37
pubmed: 33292323
Cancers (Basel). 2019 Apr 23;11(4):
pubmed: 31018563
Autoimmunity. 2006 Mar;39(2):137-41
pubmed: 16698670
Ageing Res Rev. 2011 Jul;10(3):362-9
pubmed: 20727987
Eur J Immunol. 1993 Sep;23(9):2375-8
pubmed: 8370415
J Immunol. 2004 Feb 15;172(4):2155-62
pubmed: 14764681
Aging Cell. 2013 Jun;12(3):345-57
pubmed: 23442123
Vaccine. 2011 Feb 24;29(10):1929-34
pubmed: 21236231
N Engl J Med. 2003 Apr 24;348(17):1625-38
pubmed: 12711737
Nat Med. 2017 Jul;23(7):829-838
pubmed: 28604704
Front Endocrinol (Lausanne). 2019 May 03;10:266
pubmed: 31130916
Obes Rev. 2020 Nov;21(11):e13128
pubmed: 32845580
Eur J Immunol. 2019 Feb;49(2):336-347
pubmed: 30566246
J Immunol. 2011 Jan 15;186(2):697-707
pubmed: 21148798
Aging Cell. 2015 Aug;14(4):678-88
pubmed: 26009878
Cell Rep. 2015 Jul 14;12(2):163-71
pubmed: 26146074
World J Biol Chem. 2017 May 26;8(2):120-128
pubmed: 28588755
Front Immunol. 2019 Jul 17;10:1587
pubmed: 31379820
J Clin Invest. 2017 Jan 3;127(1):5-13
pubmed: 28045397
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Lancet. 2009 Mar 28;373(9669):1083-96
pubmed: 19299006
Obesity (Silver Spring). 2017 Sep;25(9):1523-1531
pubmed: 28707376
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Diabetes. 2007 Apr;56(4):1010-3
pubmed: 17287468
Mol Aspects Med. 2013 Feb;34(1):12-29
pubmed: 23068074
Nature. 2015 Dec 3;528(7580):137-41
pubmed: 26580014
Atherosclerosis. 2008 Mar;197(1):311-7
pubmed: 17588584
Obes Res Clin Pract. 2018 Nov - Dec;12(6):513-519
pubmed: 30115554
Adipocyte. 2018;7(3):226-228
pubmed: 30001663