Time- and dose-dependent biological effects of a sub-chronic exposure to realistic doses of salicylic acid in the gills of mussel Mytilus galloprovincialis.
Acetylcholinesterase
Catalase
Gills
Glutathione S-transferase
Lipid peroxidation
Mussels
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Superoxide dismutase
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
25
01
2022
accepted:
01
07
2022
pubmed:
14
7
2022
medline:
22
11
2022
entrez:
13
7
2022
Statut:
ppublish
Résumé
Among nonsteroidal anti-inflammatory drugs (NSAIDs) commonly found in seawater and wastewater, salicylic acid (SA) represents one of the most persistent and hazardous compounds for aquatic organisms. This study was therefore designed to elucidate the biological effects of SA in mussel Mytilus galloprovincialis. During a sub-chronic exposure (12 days), mussels were exposed to five realistic concentrations of SA (C1: 0.05 μg/L; C2: 0.5 μg/L; C3: 5 μg/L; C4: 50 μg/L; C5: 100 μg/L) and gills, selected as the target organ, were collected at different time points (T3: 3 days; T5: 5 days; T12: 12 days). Exposure to SA induced no histological alterations in mussel gills, despite a relevant hemocyte infiltration was observed throughout the exposure as a defensive response to SA. Temporal modulation of glutathione S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD) activities suggested the occurrence of antioxidant and detoxifying responses against SA exposure, while lipid peroxidation (LPO), except for a partial increase at T3, was prevented. Inhibition of the cholinergic system was also reported by reduced acetylcholinesterase (AChE) activity, mainly at T12. Overall, findings from this study contribute to enlarge the current knowledge on the cytotoxicity of SA, on non-target aquatic organisms, and might for the enhancement of new ecopharmacovigilance programs and optimization of the efficacy of wastewater treatment plants for mitigation of pharmaceutical pollution in coastal areas.
Identifiants
pubmed: 35829880
doi: 10.1007/s11356-022-21866-8
pii: 10.1007/s11356-022-21866-8
doi:
Substances chimiques
Salicylic Acid
O414PZ4LPZ
Acetylcholinesterase
EC 3.1.1.7
Water Pollutants, Chemical
0
Catalase
EC 1.11.1.6
Glutathione Transferase
EC 2.5.1.18
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
88161-88171Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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