Uptake and Acceptability of MyChoices: Results of a Pilot RCT of a Mobile App Designed to Increase HIV Testing and PrEP Uptake Among Young American MSM.
HIV testing
Men who have sex with men
Mobile app
PrEP
Youth
Journal
AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
accepted:
18
05
2022
pubmed:
14
7
2022
medline:
10
11
2022
entrez:
13
7
2022
Statut:
ppublish
Résumé
Young men who have sex with men (YMSM) remain at disproportionate risk for HIV acquisition in the United States (US), yet use of evidence-based prevention strategies, including routine HIV testing and pre-exposure prophylaxis (PrEP), remain low. Smartphones and mobile app usage are nearly ubiquitous in this population. Given the potential for scalability, a mobile app to increase HIV testing and PrEP use among YMSM has the potential to make an extraordinary public health impact if efficacious. Based on extensive formative, community-engaged research, we developed a theory-driven mobile app-MyChoices-to increase HIV testing and PrEP uptake among YMSM. In a pilot randomized controlled trial (RCT), participants (n = 60) were randomized 2:1 to receive MyChoices or standard of care (SOC). Data from 3 to 6-month post-baseline assessments demonstrate that the app was highly acceptable (System Usability Score; mean = 75.8, SD = 10.7) and feasible (94% used the MyChoices app at least once; mean = 15.3 sessions, SD = 9.8). While not powered to assess efficacy, those in the MyChoices arm had 22% higher prevalence of HIV testing over follow-up compared to those in the SOC arm (NS). There was no difference in PrEP uptake. A fully-powered efficacy trial is warranted; if efficacy is demonstrated, the MyChoices app could be easily scaled to reach YMSM across the US.
Identifiants
pubmed: 35829971
doi: 10.1007/s10461-022-03724-3
pii: 10.1007/s10461-022-03724-3
doi:
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3981-3990Subventions
Organisme : NICHD NIH HHS
ID : U19 HD089881
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : P30AI050409
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : U01HD068040
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Centers for Disease Control and Prevention. HIV Surveillance Report, 2019. vol. 32; 2021. http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html . Accessed 1 June 2022.
Hess KL, Hu X, Lansky A, Mermin J, Hall HI. Lifetime risk of a diagnosis of HIV infection in the United States. Ann Epidemiol. 2017;27(4):238–43.
doi: 10.1016/j.annepidem.2017.02.003
pubmed: 28325538
pmcid: 5524204
Matthews DD, Herrick AL, Coulter RW, et al. Running backwards: consequences of current HIV incidence rates for the next generation of black MSM in the United States. AIDS Behav. 2016;20(1):7–16.
doi: 10.1007/s10461-015-1158-z
pubmed: 26267251
pmcid: 4718884
Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.
doi: 10.1056/NEJMoa1105243
pubmed: 21767103
pmcid: 3200068
Bennett CL, Marks SJ, Liu T, Clark MA, Carey MP, Merchant RC. Factors associated with lack of HIV testing among Latino immigrant and Black patients at 4 geographically and demographically diverse emergency departments. J Int Assoc Provid AIDS Care. 2020. https://doi.org/10.1177/2325958220970827 .
doi: 10.1177/2325958220970827
pubmed: 33143525
pmcid: 7675889
McCormack S, Dunn DT, Desai M, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet (London, England). 2016;387(10013):53–60.
doi: 10.1016/S0140-6736(15)00056-2
Severe P, Juste MA, Ambroise A, et al. Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. N Engl J Med. 2010;363(3):257–65.
doi: 10.1056/NEJMoa0910370
pubmed: 20647201
pmcid: 3676927
Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–99.
doi: 10.1056/NEJMoa1011205
pubmed: 21091279
pmcid: 3079639
Cooley LA, Oster AM, Rose CE, et al. Increases in HIV testing among men who have sex with men—National HIV Behavioral Surveillance System, 20 U.S. metropolitan statistical areas, 2008 and 2011. PLoS ONE. 2014;9(9):e104162.
doi: 10.1371/journal.pone.0104162
pubmed: 25180514
pmcid: 4151966
Bennett CL, Marks SJ, Rosenberger JG, et al. Factors associated with the discordance between perception of being HIV infected and HIV sexual risk taking among social media-using Black, Hispanic, and White young men who have sex with men. J Int Assoc Provid AIDS Care. 2020. https://doi.org/10.1177/2325958220919260 .
doi: 10.1177/2325958220919260
pubmed: 33143525
pmcid: 7675889
Pierce JD, Ylitalo KR, Lanning BA, Limbers CC. Sex education and HIV testing among young men who have sex with men: findings from the 2006–2010 and 2011–2015 national survey of family growth. J Acquir Immune Defic Syndr. 2018;79(2):179–85.
doi: 10.1097/QAI.0000000000001773
pubmed: 29905592
Veinot TC, Caldwell E, Loveluck J, Arnold MP, Bauermeister J. HIV testing behavior and social network characteristics and functions among young men who have sex with men (YMSM) in metropolitan detroit. AIDS Behav. 2016;20(11):2739–61.
doi: 10.1007/s10461-016-1296-y
pubmed: 26837634
pmcid: 5234266
Seth P, Walker T, Figueroa A. CDC-funded HIV testing, HIV positivity, and linkage to HIV medical care in non-health care settings among young men who have sex with men (YMSM) in the United States. AIDS Care. 2017;29(7):823–7.
doi: 10.1080/09540121.2016.1271104
pubmed: 27998184
Wejnert C, Hess KL, Rose CE, et al. Age-specific race and ethnicity disparities in HIV infection and awareness among men who have sex with men—20 US cities, 2008–2014. J Infect Dis. 2016;213(5):776–83.
doi: 10.1093/infdis/jiv500
pubmed: 26486637
Shover CL, Javanbakht M, Shoptaw S, et al. HIV preexposure prophylaxis initiation at a large community clinic: differences between eligibility, awareness, and uptake. Am J Public Health. 2018;108(10):1408–17.
doi: 10.2105/AJPH.2018.304623
pubmed: 30138062
pmcid: 6137770
Estem KS, Catania J, Klausner JD. HIV self-testing: a review of current implementation and fidelity. Curr HIV/AIDS Rep. 2016;13(2):107–15.
doi: 10.1007/s11904-016-0307-y
pubmed: 26879653
MacKellar DA, Valleroy LA, Secura GM, et al. Perceptions of lifetime risk and actual risk for acquiring HIV among young men who have sex with men. AIDS Behav. 2007;11(2):263–70.
doi: 10.1007/s10461-006-9136-0
pubmed: 16791527
Dorell CG, Sutton MY, Oster AM, et al. Missed opportunities for HIV testing in health care settings among young African American men who have sex with men: implications for the HIV epidemic. AIDS Patient Care STDS. 2011;25(11):657–64.
doi: 10.1089/apc.2011.0203
pubmed: 21923415
Elopre L, Ott C, Lambert CC, et al. Missed prevention opportunities: why young, black MSM with recent HIV diagnosis did not access HIV pre-exposure prophylaxis services. AIDS Behav. 2021;25(5):1464–73.
doi: 10.1007/s10461-020-02985-0
pubmed: 32749626
Fjeldsoe BS, Marshall AL, Miller YD. Behavior change interventions delivered by mobile telephone short-message service. Am J Prev Med. 2009;36(2):165–73.
doi: 10.1016/j.amepre.2008.09.040
pubmed: 19135907
Blas MM, Alva IE, Carcamo CP, et al. Effect of an online video-based intervention to increase HIV testing in men who have sex with men in Peru. PLoS ONE. 2010;5(5): e10448.
doi: 10.1371/journal.pone.0010448
pubmed: 20454667
pmcid: 2862715
Hirshfield S, Chiasson MA, Joseph H, et al. An online randomized controlled trial evaluating HIV prevention digital media interventions for men who have sex with men. PLoS ONE. 2012;7(10): e46252.
doi: 10.1371/journal.pone.0046252
pubmed: 23071551
pmcid: 3462792
Ko NY, Hsieh CH, Wang MC, et al. Effects of Internet popular opinion leaders (iPOL) among Internet-using men who have sex with men. J Med Internet Res. 2013;15(2): e40.
doi: 10.2196/jmir.2264
pubmed: 23439583
pmcid: 3636233
Muessig KE, Pike EC, Legrand S, Hightow-Weidman LB. Mobile phone applications for the care and prevention of HIV and other sexually transmitted diseases: a review. J Med Internet Res. 2013;15(1): e1.
doi: 10.2196/jmir.2301
pubmed: 23291245
pmcid: 3636069
Hightow-Weidman LB, Muessig K, Rosenberg E, et al. University of North Carolina/Emory Center for Innovative Technology (iTech) for addressing the HIV epidemic among adolescents and young adults in the United States: protocol and rationale for center development. JMIR Res Protoc. 2018;7(8): e10365.
doi: 10.2196/10365
pubmed: 30076126
pmcid: 6098243
Lee S, Kapogiannis BG, Allison S. Improving the youth HIV prevention and care continuums: the adolescent medicine trials network for HIV/AIDS interventions. JMIR Res Protoc. 2019;8(3): e12050.
doi: 10.2196/12050
pubmed: 30912750
pmcid: 6454340
Biello KB, Marrow E, Mimiaga MJ, Sullivan P, Hightow-Weidman L, Mayer KH. A mobile-based app (MyChoices) to increase uptake of HIV testing and pre-exposure prophylaxis by young men who have sex with men: protocol for a pilot randomized controlled trial. JMIR Res Protoc. 2019;8(1): e10694.
doi: 10.2196/10694
pubmed: 30617042
pmcid: 6329428
Sullivan PS, Zahn RJ, Wiatrek S, et al. HIV prevention via mobile messaging for men who have sex with men (M-cubed): protocol for a randomized controlled trial. JMIR Res Protoc. 2019;8(11): e16439.
doi: 10.2196/16439
pubmed: 31730043
pmcid: 6884718
Sullivan PS, Driggers R, Stekler JD, et al. Usability and acceptability of a mobile comprehensive HIV prevention app for men who have sex with men: a pilot study. JMIR Mhealth Uhealth. 2017;5(3):e26–e26.
doi: 10.2196/mhealth.7199
pubmed: 28279949
pmcid: 5364322
Sullivan PS, Stephenson R, Hirshfield S, et al. Behavioral efficacy of a sexual health mobile app for men who have sex with men: randomized controlled trial of mobile messaging for men. J Med Internet Res. 2022;24(2):e34574. https://doi.org/10.2196/34574
doi: 10.2196/34574
pubmed: 35025755
pmcid: 8851328
Biello KB, Hill-Rorie J, Valente PK, et al. Development and evaluation of a mobile app designed to increase HIV testing and pre-exposure prophylaxis use among young men who have sex with men in the United States: open pilot trial. J Med Internet Res. 2021;23(3): e25107.
doi: 10.2196/25107
pubmed: 33759792
pmcid: 8074990
Biello KB, Horvitz C, Mullin S, et al. HIV self-testing and STI self-collection via mobile apps: experiences from two pilot randomized controlled trials of young men who have sex with men. mHealth. 2021;7:26.
doi: 10.21037/mhealth-20-70
pubmed: 33898595
pmcid: 8063023
Bandura A. Health promotion by social cognitive means. Health Educ Behav. 2004;31(2):143–64.
doi: 10.1177/1090198104263660
pubmed: 15090118
Bandura A. Social cognitive theory of personality. Handb Pers. 1999;2:154–96.
Brooke JT. SUS—a quick and dirty usability scale. In: Jordan PW, Thomas B, Weerdmeester BA, McClelland AL, editors. Usability evaluation in industry. London: Taylor and Francis; 1996. p. 189–94.
Bangor A. Determining what individual SUS scores mean: adding an adjective rating scale. J Usability Stud. 2009;4(3):114–23.
Lewis JR, Sauro J. Item benchmarks for the system usability scale. J Usability Stud. 2018;13(3):158–67.
Lewis M, Bromley K, Sutton CJ, McCray G, Myers HL, Lancaster GA. Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back! Pilot Feasibility Stud. 2021;7(1):40.
doi: 10.1186/s40814-021-00770-x
pubmed: 33536076
pmcid: 7856754
Sullivan PS, Driggers R, Stekler JD, et al. Usability and acceptability of a mobile comprehensive HIV prevention app for men who have sex with men: a pilot study. JMIR Mhealth Uhealth. 2017;5(3):e26.
doi: 10.2196/mhealth.7199
pubmed: 28279949
pmcid: 5364322
Cordova D, Alers-Rojas F, Lua FM, et al. The usability and acceptability of an adolescent mHealth HIV/STI and drug abuse preventive intervention in primary care. Behav Med. 2018;44(1):36–47.
doi: 10.1080/08964289.2016.1189396
pubmed: 27223646
Ybarra ML, Prescott TL, Phillips GL 2nd, Bull SS, Parsons JT, Mustanski B. Pilot RCT results of an mHealth HIV prevention program for sexual minority male adolescents. Pediatrics. 2017. https://doi.org/10.1542/peds.2016-2999 .
doi: 10.1542/peds.2016-2999
pubmed: 29093050
DiNenno EA, Prejean J, Irwin K, et al. Recommendations for HIV screening of gay, bisexual, and other men who have sex with men—United States, 2017. Morb Mortal Wkly Rep. 2017;66(31):830–2.
doi: 10.15585/mmwr.mm6631a3
Sullivan PS, Hightow-Weidman L. Mobile apps for HIV prevention: how do they contribute to our epidemic response for adolescents and young adults? mHealth. 2021;7:36.
doi: 10.21037/mhealth-20-71
pubmed: 33898605
pmcid: 8063022
Anderson AM, Higgins MK, Ownby RL, Waldrop-Valverde D. Changes in neurocognition and adherence over six months in HIV-infected individuals with cocaine or heroin dependence. AIDS Care. 2015;27(3):333–7.
doi: 10.1080/09540121.2014.985183
pubmed: 25484035