Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID-19.
COVID-19
diabetes
inflammation
vascular dysfunction
Journal
Diabetes/metabolism research and reviews
ISSN: 1520-7560
Titre abrégé: Diabetes Metab Res Rev
Pays: England
ID NLM: 100883450
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
31
05
2022
received:
06
08
2021
accepted:
03
06
2022
pubmed:
14
7
2022
medline:
6
10
2022
entrez:
13
7
2022
Statut:
ppublish
Résumé
Several reports indicate that diabetes determines an increased mortality risk in patients with coronavirus disease 19 (COVID-19) and a good glycaemic control appears to be associated with more favourable outcomes. Evidence also supports that COVID-19 pneumonia only accounts for a part of COVID-19 related deaths. This disease is indeed characterised by abnormal inflammatory response and vascular dysfunction, leading to the involvement and failure of different systems, including severe acute respiratory distress syndrome, coagulopathy, myocardial damage and renal failure. Inflammation and vascular dysfunction are also well-known features of hyperglycemia and diabetes, making up the ground for a detrimental synergistic combination that could explain the increased mortality observed in hyperglycaemic patients. In this work, we conduct a narrative review on this intriguing connection. Together with this, we also present the clinical characteristics, outcomes, laboratory and histopathological findings related to this topic of a cohort of nearly 1000 subjects with COVID-19 admitted to a third-level Hospital in Milan. We found an increased mortality in subjects with COVID-19 and diabetes, together with an altered inflammatory profile. This may support the hypothesis that diabetes and COVID-19 meet at the crossroads of inflammation and vascular dysfunction. (ClinicalTrials.gov NCT04463849 and NCT04382794).
Identifiants
pubmed: 35830597
doi: 10.1002/dmrr.3565
pmc: PMC9349661
doi:
Banques de données
ClinicalTrials.gov
['NCT04382794', 'NCT04463849']
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3565Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK072381
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
JACC Basic Transl Sci. 2020 Apr 10;5(5):537-542
pubmed: 32292847
Life Sci. 2000 Jun 8;67(3):291-300
pubmed: 10983873
Diabetes Res Clin Pract. 2020 Nov;169:108454
pubmed: 32971157
Acta Diabetol. 1999 Jun;36(1-2):67-72
pubmed: 10436255
Cardiovasc Diabetol. 2020 Oct 1;19(1):164
pubmed: 33004045
Diabetes. 1990 Mar;39(3):271-5
pubmed: 2407580
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Diabetes. 2010 Dec;59(12):2994-6
pubmed: 21115782
Ann Thorac Surg. 2014 Mar;97(3):851-7
pubmed: 24315405
Circulation. 2002 Oct 15;106(16):2067-72
pubmed: 12379575
Circ Res. 2020 May 8;126(10):1443-1455
pubmed: 32252591
JAMA. 2003 Jun 4;289(21):2801-9
pubmed: 12734147
Drugs. 2020 Sep;80(13):1267-1292
pubmed: 32696108
Cardiovasc Res. 2020 May 1;116(6):1097-1100
pubmed: 32227090
Circ Res. 2020 May 8;126(10):1456-1474
pubmed: 32264791
Transplantation. 2006 May 15;81(9):1274-7
pubmed: 16699454
PLoS One. 2016 Nov 3;11(11):e0165978
pubmed: 27812197
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
PLoS One. 2019 May 6;14(5):e0216397
pubmed: 31059556
J Clin Invest. 2020 Dec 1;130(12):6409-6416
pubmed: 32809969
Diabetologia. 2022 May;65(5):879-894
pubmed: 35211778
Autoimmun Rev. 2020 Jul;19(7):102569
pubmed: 32376394
Diabetologia. 2021 Apr;64(4):778-794
pubmed: 33599800
J Endocrinol Invest. 2020 Jun;43(6):867-869
pubmed: 32222956
World J Gastroenterol. 2014 Jul 21;20(27):9128-37
pubmed: 25083086
Lancet Diabetes Endocrinol. 2020 Jun;8(6):546-550
pubmed: 32334646
Am J Transplant. 2020 Nov;20(11):2975-2982
pubmed: 32777170
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Am J Med Sci. 2022 Sep;364(3):251-256
pubmed: 35469768
Am Heart J. 2022 May;247:76-89
pubmed: 35143744
Diabetes Res Clin Pract. 2020 Apr;162:108132
pubmed: 32234504
Int J Mol Sci. 2020 Jul 12;21(14):
pubmed: 32664699
J Thromb Haemost. 2020 May;18(5):1020-1022
pubmed: 32239799
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Diabetes Care. 2020 Jul;43(7):1427-1432
pubmed: 32409501
Cell Metab. 2020 Jun 2;31(6):1068-1077.e3
pubmed: 32369736
Diabetes Metab Res Rev. 2020 Nov;36(8):e3330
pubmed: 32336007
Diabetes Metab Res Rev. 2020 Mar 31;:e3319
pubmed: 32233013
Diabetes Care. 2020 Jul;43(7):1382-1391
pubmed: 32409504
FASEB J. 2022 Jan;36(1):e22052
pubmed: 34862979
Front Microbiol. 2019 Jan 29;10:50
pubmed: 30761102
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Exp Diabetes Res. 2012;2012:471823
pubmed: 22474422
J Thromb Haemost. 2020 Jul;18(7):1747-1751
pubmed: 32302448
Nat Metab. 2021 Jun;3(6):774-785
pubmed: 34035524
Nat Commun. 2020 Jul 6;11(1):3434
pubmed: 32632085
BMJ Open. 2022 Apr 12;12(4):e053961
pubmed: 35414547
Diabetes Res Clin Pract. 2020 May;163:108186
pubmed: 32360400
Lancet. 2000 Mar 4;355(9206):773-8
pubmed: 10711923
Diabetes Care. 2018 Mar;41(3):513-521
pubmed: 29330152
Cell Metab. 2020 Sep 1;32(3):437-446.e5
pubmed: 32697943
Diabetes Care. 2018 Oct;41(10):2127-2135
pubmed: 30104296
J Med Virol. 2020 Jul;92(7):770-775
pubmed: 32293710
Histochem Cell Biol. 2004 Oct;122(4):333-8
pubmed: 15257460
Diabet Med. 2006 Jun;23(6):623-8
pubmed: 16759303
Diabetes Care. 2020 Jul;43(7):1399-1407
pubmed: 32409498
Acta Diabetol. 2020 Jul;57(7):779-783
pubmed: 32506195
Lancet Rheumatol. 2020 Jul;2(7):e437-e445
pubmed: 32835247
Blood. 2020 Jun 4;135(23):2033-2040
pubmed: 32339221
Lancet Rheumatol. 2020 Aug;2(8):e474-e484
pubmed: 32835257
JCI Insight. 2021 Dec 22;6(24):
pubmed: 34784300
J Thromb Haemost. 2020 Sep;18(9):2138-2144
pubmed: 32881336
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Diabetes Care. 2020 Dec;43(12):2999-3006
pubmed: 32994187
BMJ Open Diabetes Res Care. 2020 Apr;8(1):
pubmed: 32345579
Acta Diabetol. 2019 Mar;56(3):341-354
pubmed: 30478781
Eur Respir J. 2020 Nov 26;56(5):
pubmed: 32732332
Diabetes Res Clin Pract. 2021 Jan;171:108444
pubmed: 32946854
J Thromb Haemost. 2020 Jul;18(7):1559-1561
pubmed: 32302453
Br J Pharmacol. 2020 Nov;177(21):4825-4844
pubmed: 32333398
Nat Metab. 2020 Jul;2(7):572-585
pubmed: 32694793
J Clin Med. 2021 Dec 23;11(1):
pubmed: 35011805
Diabetes Metab Res Rev. 2021 Mar;37(3):e3402
pubmed: 32871617
Nat Microbiol. 2020 Apr;5(4):562-569
pubmed: 32094589
Anaesth Crit Care Pain Med. 2020 Jun;39(3):381-382
pubmed: 32418867
Front Cell Dev Biol. 2021 Sep 13;9:730621
pubmed: 34589494
Nat Rev Immunol. 2020 Jun;20(6):355-362
pubmed: 32376901
J Diabetes. 2017 May;9(5):434-449
pubmed: 28044409
Crit Care Med. 2012 Dec;40(12):3180-8
pubmed: 22971590
N Engl J Med. 2020 Dec 10;383(24):2333-2344
pubmed: 33085857
Lancet Rheumatol. 2020 Jul;2(7):e393-e400
pubmed: 32835245
Nat Rev Immunol. 2020 Jul;20(7):389-391
pubmed: 32439870
Front Physiol. 2020 Oct 06;11:574753
pubmed: 33123031
Nat Rev Immunol. 2020 May;20(5):269-270
pubmed: 32273594
J Am Heart Assoc. 2021 Aug 3;10(15):e021154
pubmed: 34320843
Clin Chem Lab Med. 2020 Jun 25;58(7):1021-1028
pubmed: 32286245
Lancet Diabetes Endocrinol. 2020 Sep;8(9):782-792
pubmed: 32687793
Immunol Lett. 2000 Nov 1;74(3):239-44
pubmed: 11064109
J Clin Endocrinol Metab. 2000 Jul;85(7):2572-5
pubmed: 10902810
Open Forum Infect Dis. 2019 Aug 16;6(10):ofz358
pubmed: 31660337
J Card Surg. 2016 Jul;31(7):410-5
pubmed: 27212455
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F266-F275
pubmed: 27852610
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Lancet Respir Med. 2020 Jun;8(6):e46-e47
pubmed: 32353251
Diabetes Metab Res Rev. 2022 Jul;38(5):e3526
pubmed: 35262260
Diabetes Metab Res Rev. 2022 Oct;38(7):e3565
pubmed: 35830597
Clin Infect Dis. 2021 May 4;72(9):e373-e381
pubmed: 32785710
Thromb Res. 2020 Jul;191:145-147
pubmed: 32291094
Diabetologia. 2020 Aug;63(8):1500-1515
pubmed: 32472191
J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973
pubmed: 32311448
PLoS One. 2010 Mar 29;5(3):e9923
pubmed: 20360867
Microorganisms. 2020 Jun 30;8(7):
pubmed: 32629788
J Endocrinol Invest. 2021 Jul;44(7):1379-1386
pubmed: 33512688
Transplantation. 2003 Apr 27;75(8):1296-301
pubmed: 12717219
Circulation. 2020 May 19;141(20):1648-1655
pubmed: 32200663
Sci Rep. 2016 Jun 13;6:27770
pubmed: 27291987
Diabet Med. 1997 Jan;14(1):29-34
pubmed: 9017350
Biochem Biophys Res Commun. 2020 Feb 17;:
pubmed: 32081428
J Thromb Haemost. 2020 May;18(5):1094-1099
pubmed: 32220112
FEMS Immunol Med Microbiol. 1999 Dec;26(3-4):259-65
pubmed: 10575137
Immunity. 2018 Jul 17;49(1):6-8
pubmed: 30021147
Food Chem Toxicol. 2020 Nov;145:111694
pubmed: 32822775
Horm Metab Res. 2000 Oct;32(10):407-12
pubmed: 11069205
J Diabetes Sci Technol. 2020 Jul;14(4):813-821
pubmed: 32389027
J Diabetes Complications. 2016 May-Jun;30(4):738-45
pubmed: 26781070
Crit Care Med. 2008 May;36(5):1551-8
pubmed: 18434880
Biomedicines. 2020 Jun 29;8(7):
pubmed: 32610588
Am J Physiol Lung Cell Mol Physiol. 2021 Mar 1;320(3):L422-L429
pubmed: 33404363
FASEB J. 2022 Feb;36(2):e22137
pubmed: 35066939
Diabetes Obes Metab. 2020 Oct;22(10):1946-1950
pubmed: 32463179
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
Diabetes Metab. 2020 Oct;46(5):403-405
pubmed: 32447102
Am J Transplant. 2010 Dec;10(12):2690-700
pubmed: 21114646
Vasc Med. 2020 Oct;25(5):471-478
pubmed: 32558620
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
J Clin Invest. 2018 Aug 1;128(8):3490-3503
pubmed: 30010623
Cardiovasc Res. 2020 Aug 1;116(10):1666-1687
pubmed: 32352535
Diabetes Care. 2020 Jul;43(7):1416-1426
pubmed: 32430459
Cardiovasc Diabetol. 2018 Aug 31;17(1):121
pubmed: 30170601
Endocrinology. 2020 Oct 1;161(10):
pubmed: 32603424
Br J Haematol. 2021 Jul;194(1):44-52
pubmed: 34053084
Blood. 2020 Jul 23;136(4):489-500
pubmed: 32492712
N Engl J Med. 2021 Jul 22;385(4):320-329
pubmed: 34192428