Retrograde movements determine effective stem cell numbers in the intestine.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2022
Historique:
received: 18 02 2020
accepted: 10 06 2022
pubmed: 14 7 2022
medline: 23 7 2022
entrez: 13 7 2022
Statut: ppublish

Résumé

The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts

Identifiants

pubmed: 35831497
doi: 10.1038/s41586-022-04962-0
pii: 10.1038/s41586-022-04962-0
pmc: PMC7614894
mid: EMS182587
doi:

Substances chimiques

Lgr5 protein, mouse 0
Receptors, G-Protein-Coupled 0
Wnt Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

548-554

Subventions

Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : European Research Council
ID : 758617
Pays : International
Organisme : European Research Council
ID : 851288
Pays : International
Organisme : Wellcome Trust
ID : 219478/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098357/Z/12/Z
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Maria Azkanaz (M)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Bernat Corominas-Murtra (B)

Institute of Biology, University of Graz, Graz, Austria.
Institute for Science and Technology Austria, Klosterneuburg, Austria.

Saskia I J Ellenbroek (SIJ)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Lotte Bruens (L)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Anna T Webb (AT)

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.

Dimitrios Laskaris (D)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Koen C Oost (KC)

Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.

Simona J A Lafirenze (SJA)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.
Hubrecht Institute, Royal Academy of Arts and Sciences, University Medical Centre Utrecht, Utrecht, The Netherlands.

Karl Annusver (K)

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.

Hendrik A Messal (HA)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Sharif Iqbal (S)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.

Dustin J Flanagan (DJ)

CRUK Beatson Institute, Glasgow, UK.
Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.

David J Huels (DJ)

Oncode Institute, Utrecht, The Netherlands.
CRUK Beatson Institute, Glasgow, UK.
Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Felipe Rojas-Rodríguez (F)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Miguel Vizoso (M)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Oncode Institute, Utrecht, The Netherlands.

Maria Kasper (M)

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.

Owen J Sansom (OJ)

CRUK Beatson Institute, Glasgow, UK.
Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

Hugo J Snippert (HJ)

Oncode Institute, Utrecht, The Netherlands.
Molecular Cancer Research, Centre for Molecular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands.

Prisca Liberali (P)

Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.
University of Basel, Basel, Switzerland.

Benjamin D Simons (BD)

Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.
Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.

Pekka Katajisto (P)

Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. pekka.katajisto@ki.se.
Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@ki.se.
Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. pekka.katajisto@ki.se.

Edouard Hannezo (E)

Institute for Science and Technology Austria, Klosterneuburg, Austria. edouard.hannezo@ist.ac.at.

Jacco van Rheenen (J)

Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. j.v.rheenen@nki.nl.
Oncode Institute, Utrecht, The Netherlands. j.v.rheenen@nki.nl.

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Classifications MeSH