Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.

Amino Acid Motifs Binding Sites Cryoelectron Microscopy Guanosine Triphosphate / metabolism Humans Intracellular Signaling Peptides and Proteins / chemistry MAP Kinase Signaling System Multiprotein Complexes / chemistry Mutation, Missense Phosphorylation Protein Binding Protein Phosphatase 1 / chemistry Protein Stability raf Kinases ras Proteins / chemistry

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 13 01 2022
accepted: 02 06 2022
pubmed: 14 7 2022
medline: 11 9 2022
entrez: 13 7 2022
Statut: ppublish

Résumé

Receptor tyrosine kinase (RTK)-RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell proliferation and survival. The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the RAF family of proteins to potentiate MAPK signalling

Identifiants

DOI: 10.1038/s41586-022-04928-2 PMID: 35831509 PMC: PMC9694338
pubmed: 35831509
doi: 10.1038/s41586-022-04928-2
pii: 10.1038/s41586-022-04928-2
pmc: PMC9694338
mid: NIHMS1844861
doi:

Substances chimiques

Intracellular Signaling Peptides and Proteins 0
MRAS protein, human 0
Multiprotein Complexes 0
SHOC2 protein, human 0
Guanosine Triphosphate 86-01-1
raf Kinases EC 2.7.11.1
Protein Phosphatase 1 EC 3.1.3.16
ras Proteins EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

408-415

Subventions

Organisme : NCI NIH HHS
ID : U01 CA224146
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197709
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA218420
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176058
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA243290
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA250549
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA127003
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

Références

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Auteurs

Jason J Kwon (JJ)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Behnoush Hajian (B)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Yuemin Bian (Y)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-5845-772X

Lucy C Young (LC)

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

Alvaro J Amor (AJ)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

James R Fuller (JR)

Helix Biostructures, Indianapolis, IN, USA.
ORCID: 0000-0002-9029-0923

Cara V Fraley (CV)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Abbey M Sykes (AM)

Harvard Medical School, Boston, Massachusetts, USA.
Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jonathan So (J)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Joshua Pan (J)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Laura Baker (L)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Sun Joo Lee (SJ)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Douglas B Wheeler (DB)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

David L Mayhew (DL)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard Medical School, Boston, Massachusetts, USA.

Nicole S Persky (NS)

Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Xiaoping Yang (X)

Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-6811-4915

David E Root (DE)

Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0001-5122-861X

Anthony M Barsotti (AM)

Deerfield Discovery and Development, Deerfield Management, New York, NY, USA.

Andrew W Stamford (AW)

Deerfield Discovery and Development, Deerfield Management, New York, NY, USA.

Charles K Perry (CK)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Alex Burgin (A)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Frank McCormick (F)

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA.
ORCID: 0000-0002-6619-7120

Christopher T Lemke (CT)

Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. clemke@broadinstitute.org.

William C Hahn (WC)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_hahn@dfci.harvard.edu.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_hahn@dfci.harvard.edu.
Harvard Medical School, Boston, Massachusetts, USA. william_hahn@dfci.harvard.edu.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. william_hahn@dfci.harvard.edu.
ORCID: 0000-0003-2840-9791

Andrew J Aguirre (AJ)

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. andrew_aguirre@dfci.harvard.edu.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. andrew_aguirre@dfci.harvard.edu.
Harvard Medical School, Boston, Massachusetts, USA. andrew_aguirre@dfci.harvard.edu.
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. andrew_aguirre@dfci.harvard.edu.
ORCID: 0000-0002-0701-6203

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Motifs d'acides aminés › Structure-function analysis of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structure-function analysis of the...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Structure-function analysis of the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Guanosine triphosphate › Structure-function analysis of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-function analysis of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Structure-function analysis of the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Structure-function analysis of the...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Structure-function analysis of the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › Structure-function analysis of the...
questionsmedicales.fr › Métabolisme › Phosphorylation › Structure-function analysis of the...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structure-function analysis of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein Phosphatase 1 › Structure-function analysis of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Structure-function analysis of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Kinases raf › Structure-function analysis of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G ras › Structure-function analysis of the...