Specific (sialyl-)Lewis core 2
Tumor associated carbohydrate antigens (TACAs)
glycomics
mass spectrometry
therapeutic target
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
03
2022
accepted:
13
05
2022
entrez:
14
7
2022
pubmed:
15
7
2022
medline:
16
7
2022
Statut:
epublish
Résumé
Cells are covered with a dense layer of carbohydrates, some of which are solely present on neoplastic cells. The so-called tumor-associated carbohydrate antigens (TACAs) are increasingly recognized as promising targets for immunotherapy. These carbohydrates differ from those of the surrounding non-cancerous tissues and contribute to the malignant phenotype of the cancer cells by promoting proliferation, metastasis, and immunosuppression. However, due to tumor tissue heterogeneity and technological limitations, TACAs are insufficiently explored.
Identifiants
pubmed: 35832079
doi: 10.7150/thno.72818
pii: thnov12p4498
pmc: PMC9254241
doi:
Substances chimiques
Antigens, Tumor-Associated, Carbohydrate
0
Carbohydrates
0
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4498-4512Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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