Instillation of a Dry Powder in Nasal Casts: Parameters Influencing the Olfactory Deposition With Uni- and Bi-Directional Devices.
artificial mucus
bidirectional device
nasal cast
nasal spray
nose-to-brain
powder
Journal
Frontiers in medical technology
ISSN: 2673-3129
Titre abrégé: Front Med Technol
Pays: Switzerland
ID NLM: 101772626
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
04
2022
accepted:
26
05
2022
entrez:
14
7
2022
pubmed:
15
7
2022
medline:
15
7
2022
Statut:
epublish
Résumé
Nose-to-brain delivery is a promising way to reach the central nervous system with therapeutic drugs. However, the location of the olfactory region at the top of the nasal cavity complexifies this route of administration. In this study, we used a 3D-printed replica of a nasal cavity (a so-called "nasal cast") to reproduce
Identifiants
pubmed: 35832236
doi: 10.3389/fmedt.2022.924501
pmc: PMC9273033
doi:
Types de publication
Journal Article
Langues
eng
Pagination
924501Informations de copyright
Copyright © 2022 Rigaut, Deruyver, Goole, Haut and Lambert.
Déclaration de conflit d'intérêts
The authors declare that this study received equipment from AptarGroup and IP Med. The equipment providers were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.
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