Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow.
Mesothelioma
angiogenesis
orthotopic mouse model of mesothelioma
vascularization
Journal
Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
12
10
2021
accepted:
24
04
2022
entrez:
14
7
2022
pubmed:
15
7
2022
medline:
15
7
2022
Statut:
ppublish
Résumé
The microanatomical steps of malignant pleural mesothelioma (MPM) vascularization and the resistance mechanisms to anti-angiogenic drugs in MPM are unclear. We investigated the vascularization of intrapleurally implanted human P31 and SPC111 MPM cells. We also assessed MPM cell's motility, invasion and interaction with endothelial cells P31 cells exhibited significantly higher two-dimensional (2D) motility and three-dimensional (3D) invasion than SPC111 cells Here, we report two distinct growth patterns of orthotopically implanted human MPM xenografts. In the invasive pattern, MPM cells invade and thus co-opt peritumoral capillary plexuses. In the pushing/desmoplastic pattern, MPM cells induce a desmoplastic response within the underlying tissue which allows the ingrowth of a nutritive vasculature from the pleura.
Sections du résumé
Background
UNASSIGNED
The microanatomical steps of malignant pleural mesothelioma (MPM) vascularization and the resistance mechanisms to anti-angiogenic drugs in MPM are unclear.
Methods
UNASSIGNED
We investigated the vascularization of intrapleurally implanted human P31 and SPC111 MPM cells. We also assessed MPM cell's motility, invasion and interaction with endothelial cells
Results
UNASSIGNED
P31 cells exhibited significantly higher two-dimensional (2D) motility and three-dimensional (3D) invasion than SPC111 cells
Conclusions
UNASSIGNED
Here, we report two distinct growth patterns of orthotopically implanted human MPM xenografts. In the invasive pattern, MPM cells invade and thus co-opt peritumoral capillary plexuses. In the pushing/desmoplastic pattern, MPM cells induce a desmoplastic response within the underlying tissue which allows the ingrowth of a nutritive vasculature from the pleura.
Identifiants
pubmed: 35832452
doi: 10.21037/tlcr-21-828
pii: tlcr-11-06-991
pmc: PMC9271443
doi:
Types de publication
Journal Article
Langues
eng
Pagination
991-1008Subventions
Organisme : Austrian Science Fund FWF
ID : I 3977
Pays : Austria
Informations de copyright
2022 Translational Lung Cancer Research. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-21-828/coif). BD, BH and VL were supported by the Austrian Science Fund (FWF I2872 to BH; FWF I3522 to VL; FWF I3977 and I4677 to BD). BD, ZM, IH, SP and AC acknowledge funding from the Hungarian National Research, Development and Innovation Office (KH130356 and KKP126790 to BD; 2020-1.1.6-JÖVŐ and TKP2021-EGA-33 to BD and ZM; ANN128666 to IH; SNN 114490 to SP; ANN 132225 to AC). VL is a recipient of the Bolyai Research Scholarship of the Hungarian Academy of Sciences and the UNKP-19-4 New National Excellence Program of the Ministry for Innovation and Technology. ZM was supported by the UNKP-20-3 and UNKP-21-3 New National Excellence Program of the Ministry for Innovation and Technology of Hungary, and by the Hungarian Respiratory Society (MPA #2020). ZL was supported by the ESMO Translational Research Fellowship. The other authors have no conflicts of interest to declare.
Références
J Pathol. 2001 Apr;193(4):468-75
pubmed: 11276005
Lancet. 2016 Apr 2;387(10026):1405-1414
pubmed: 26719230
Front Oncol. 2020 Feb 11;10:101
pubmed: 32117751
Lancet Respir Med. 2019 Jul;7(7):569-580
pubmed: 31103412
Eur Respir J. 2020 Jun 11;55(6):
pubmed: 32451346
BMC Cancer. 2006 May 17;6:130
pubmed: 16704740
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15779-84
pubmed: 16249343
Front Oncol. 2020 Mar 25;10:388
pubmed: 32269966
Exp Cell Res. 1996 Apr 10;224(1):39-51
pubmed: 8612690
Int J Mol Sci. 2018 Jun 26;19(7):
pubmed: 29949929
F1000Res. 2018 Aug 3;7:1184
pubmed: 30410729
Clin Cancer Res. 2002 Apr;8(4):1008-13
pubmed: 11948107
Am J Pathol. 2004 Oct;165(4):1071-85
pubmed: 15466375
Front Genet. 2018 Jul 04;9:232
pubmed: 30022998
Semin Oncol. 2002 Feb;29(1):2-17
pubmed: 11836664
Clin Cancer Res. 2007 Oct 1;13(19):5918-25
pubmed: 17908988
Am J Respir Crit Care Med. 2014 Oct 1;190(7):763-72
pubmed: 25188816
Cancer Commun (Lond). 2018 Jul 5;38(1):46
pubmed: 29976246
Clin Cancer Res. 2018 Aug 1;24(15):3729-3740
pubmed: 29724868
J Cell Biol. 1998 Feb 23;140(4):947-59
pubmed: 9472045
J Clin Oncol. 2017 Nov 1;35(31):3591-3600
pubmed: 28892431
Lung Cancer. 2005 May;48(2):291-6
pubmed: 15829331
Sci Rep. 2019 Oct 7;9(1):14363
pubmed: 31591456
Eur J Cancer. 2009 Jun;45(9):1684-91
pubmed: 19318229
J Cell Sci. 1995 Jun;108 ( Pt 6):2369-79
pubmed: 7673356
PLoS One. 2018 Sep 4;13(9):e0203203
pubmed: 30180178
Am J Pathol. 2011 Sep;179(3):1573-85
pubmed: 21827961
J Pathol. 1996 Feb;178(2):151-60
pubmed: 8683381
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Clin Oncol. 2002 Nov 1;20(21):4368-80
pubmed: 12409337
Br J Cancer. 2001 Sep 14;85(6):863-8
pubmed: 11556838
Cancer. 2011 May 15;117(10):2202-8
pubmed: 21523734
Cancer Res. 1997 Feb 15;57(4):765-72
pubmed: 9044858
Cancer Lett. 2008 Jun 28;265(1):55-66
pubmed: 18364248
Am J Pathol. 2007 Jan;170(1):1-15
pubmed: 17200177
MedGenMed. 2007 May 10;9(2):32
pubmed: 17955087
Lung Cancer. 2012 Jun;76(3):393-6
pubmed: 22197613
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Curr Opin Oncol. 2021 Jan;33(1):80-86
pubmed: 33186182
J Cell Biol. 2012 Feb 20;196(4):395-406
pubmed: 22351925
Front Oncol. 2020 Feb 18;10:126
pubmed: 32133285
J Anat. 1953 Oct;87(4):387-406
pubmed: 13117757
Lung Cancer. 2005 Oct;50(1):83-6
pubmed: 15951053
Sci Rep. 2020 Nov 18;10(1):20114
pubmed: 33208866
Pathology. 2016 Dec;48(7):650-659
pubmed: 27956272