COVID-19 vaccination-triggered cluster headache episodes with frequent attacks.
COVID-19 vaccination
Cluster headache
headache
Journal
Cephalalgia : an international journal of headache
ISSN: 1468-2982
Titre abrégé: Cephalalgia
Pays: England
ID NLM: 8200710
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
15
7
2022
medline:
8
11
2022
entrez:
14
7
2022
Statut:
ppublish
Résumé
The pathophysiology of cluster headache and how cluster episodes are triggered, are still poorly understood. Recurrent inflammation of the trigeminovascular system has been hypothesized. It was noted that some long-term attack-free cluster headache patients suddenly developed a new cluster episode shortly after COVID-19 vaccination. Cases are described from patients with cluster headache who reported a new cluster episode within days after COVID-19 vaccination. All cases were seen in a tertiary university referral center and a general hospital in the Netherlands between March 2021 and December 2021, when the first COVID-19 vaccinations were carried out in The Netherlands. Clinical characteristics of the previous and new cluster episodes, and time between the onset of a new cluster episode and a previous COVID-19 vaccination were reported. We report seven patients with cluster headache, who had been attack-free for a long time, in whom a new cluster episode occurred within a few days after a COVID-19 vaccination. COVID-19 vaccinations may trigger new cluster episodes in patients with cluster headache, possibly by activating a pro-inflammatory state of the trigeminocervical complex. COVID-19 vaccinations may also exacerbate other neuroinflammatory conditions. .
Sections du résumé
BACKGROUND
The pathophysiology of cluster headache and how cluster episodes are triggered, are still poorly understood. Recurrent inflammation of the trigeminovascular system has been hypothesized. It was noted that some long-term attack-free cluster headache patients suddenly developed a new cluster episode shortly after COVID-19 vaccination.
METHODS
Cases are described from patients with cluster headache who reported a new cluster episode within days after COVID-19 vaccination. All cases were seen in a tertiary university referral center and a general hospital in the Netherlands between March 2021 and December 2021, when the first COVID-19 vaccinations were carried out in The Netherlands. Clinical characteristics of the previous and new cluster episodes, and time between the onset of a new cluster episode and a previous COVID-19 vaccination were reported.
RESULTS
We report seven patients with cluster headache, who had been attack-free for a long time, in whom a new cluster episode occurred within a few days after a COVID-19 vaccination.
INTERPRETATION
COVID-19 vaccinations may trigger new cluster episodes in patients with cluster headache, possibly by activating a pro-inflammatory state of the trigeminocervical complex. COVID-19 vaccinations may also exacerbate other neuroinflammatory conditions. .
Identifiants
pubmed: 35833226
doi: 10.1177/03331024221113207
pmc: PMC9638705
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1420-1424Références
Neurosurgery. 2021 Jan 13;88(2):375-383
pubmed: 32985662
Cephalalgia. 2022 Apr;42(4-5):366-375
pubmed: 34510919
Cephalalgia. 2015 Oct;35(11):969-78
pubmed: 25573893
Brain Commun. 2021 Jul 23;3(3):fcab169
pubmed: 34405142
JAMA Neurol. 2018 Oct 1;75(10):1187-1197
pubmed: 29987329
Clin Immunol. 2020 Aug;217:108480
pubmed: 32461193
Pain Ther. 2021 Dec;10(2):1309-1330
pubmed: 34313952
Cephalalgia. 2021 Jun;41(7):799-809
pubmed: 33472428
Cephalalgia. 2022 Mar;42(3):266-272
pubmed: 34407651
Cephalalgia. 2019 Dec;39(14):1855-1866
pubmed: 31142137
Front Neurol. 2021 Oct 22;12:765954
pubmed: 34744992
Cephalalgia. 2015 Apr;35(4):317-26
pubmed: 24958681
Lancet Neurol. 2018 Jan;17(1):75-83
pubmed: 29174963
Pain. 2017 Apr;158(4):543-559
pubmed: 28301400
Headache. 2012 Jan;52(1):99-113
pubmed: 22077141
J Neuroradiol. 2022 Nov;49(6):428-430
pubmed: 35381296