The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats.
Alkaline Phosphatase
Animals
Antioxidants
/ metabolism
Brain
/ metabolism
Brain Injuries
Epilepsy
/ chemically induced
Glutathione
/ metabolism
Male
Nitric Oxide
Oxidants
/ pharmacology
Oxidative Stress
Pentylenetetrazole
/ toxicity
Peroxidase
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
Sulfur
/ metabolism
Vitamin U
/ pharmacology
Xanthine Oxidase
brain
oxidative stress
pentylenetetrazole
seizure
vitamin U
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
revised:
07
04
2022
received:
04
08
2021
accepted:
01
07
2022
pubmed:
15
7
2022
medline:
14
10
2022
entrez:
14
7
2022
Statut:
ppublish
Résumé
Pentylenetetrazole (PTZ) is preferred for experimental epilepsy induction. PTZ damages brain and other organs by elevating oxidative substances. Vitamin U (Vit U) is sulfur derivative substance that proved to be an excellent antioxidant. The current study was intended to determine the protective role of Vit U on PTZ-induced brain damage. Male Sprague-Dawley rats were separated into four groups. The Control group (Group I), was given saline for 7 days intraperitoneally (i.p); Vit U (Group II) was given as 50 mg/kg/day for 7 days by gavage; PTZ was injected into animals (Group III) at a single dose of 60 mg/kg, by i.p; PTZ + Vit U group (Group IV) was administered PTZ and Vit U in same dose and time as aforementioned. After the experiment was terminated, brain tissues were taken for the preparation of homogenates. In the PTZ group, glutathione and lipid peroxidation levels, alkaline phosphatase, myeloperoxidase, xanthine oxidase, acetylcholine esterase, antioxidant enzyme activities, total oxidant status, oxidative stress index, reactive oxygen species, and nitric oxide levels were increased. However, total antioxidant capacity was decreased in the PTZ group. Vit U ameliorated these effects in the PTZ-induced brain damage. Consequently, we can suggest that Vit U protected brain tissue via its antioxidant feature against PTZ kindling epilepsy.
Substances chimiques
Antioxidants
0
Oxidants
0
Reactive Oxygen Species
0
Nitric Oxide
31C4KY9ESH
Vitamin U
3485Y39925
Sulfur
70FD1KFU70
Peroxidase
EC 1.11.1.7
Xanthine Oxidase
EC 1.17.3.2
Alkaline Phosphatase
EC 3.1.3.1
Glutathione
GAN16C9B8O
Pentylenetetrazole
WM5Z385K7T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23169Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
M. N. Patel, Free. Radic. Res. 2002, 36, 1139.
J. K. Kleen, R. C. Scott, P. P. Lenck-Santini, G. L. Holmes, Cognitive and Behavioral Co-morbidities of Epilepsy, Jasper's Basic Mechanisms of the Epilepsies, 2012.
A. Mesdaghinia, M. Alinejad, A. Abed, A. Heydari, H. R. Banafshe, Nutr. Neurosci. 2019, 22, 165.
B. Martinc, I. Grabnar, T. Vovk, Curr. Neuropharmacol. 2012, 10, 328.
M. Kumar, P. Kumar, Neurosci. Res. 2017, 120, 8.
A. M. Hussein, M. Eldosoky, M. El-Shafey, M. El-Mesery, A. N. Ali, K. M. Abbas, O. A. Abulseoud, Can. J. Physiol. Pharmacol. 2019, 97, 37.
A. Dhir, Curr. Protoc. Neurosci. 2012, 58, 9.37.1.
N. Ates, N. Esen, G. Ilbay, Pharmacol. Res. 1999, 39, 305.
P. K. Kola, A. Akula, L. S. Nissankara Rao, R. C. S. R. Danduga, A. Mohammad, S. Ineedi, Epilepsy Behav. 2018, 89, 159.
S. Kumari, A. G. Mazumder, A. Bhardwaj, D. Singh, Prostaglandins Leukot. Essent. Fatty Acids 2019, 143, 15.
E. H. Reynolds, M. R. Trimble, Drugs 1985, 29, 570.
G. S. Taiwe, F. C. Moto, E. R. Ayissi, G. T. Ngoupaye, J. S. Njapdounke, G. C. Nkantchoua, N. Kouemou, J. P. Omam, A. K. Kandeda, S. Pale, D. Pahaye, E. Ngo Bum, Epilepsy Behav. 2015, 43, 100.
I. Rácz, E. Páldi, G. Szalai, T. Janda, M. Pál, D. Lásztity, J. Plant Physiol. 2008, 165, 1483.
K. Seri, T. Matsuo, T. Taniguchi, K. Amemiya, M. Kudo, G. Saito, T. Kato, Arzneimittelforsch. 1980, 30, 1694.
A. S. Salim, J. Pharm. Sci. 1991, 80, 539.
B. B. Sokmen, S. Tunali, R. Yanardag, Food Chem. Toxicol. 2012, 50, 3562.
S. Oktay, G. Bayrak, B. Alev, H. Ipekci, U. V. Ustundag, I. B. Turkyilmaz, R. Pisiriciler, E. Emekli-Alturfan, T. Tunali-Akbay, R. Yanardag, A. Yarat, Naunyn Schmiedebergs Arch. Pharmacol. 2018, 391, 177.
W. S. Kim, Y. J. Yang, H. G. Min, M. G. Song, J. S. Lee, K. Y. Park, J. J. Kim, J. H. Sung, J. S. Choi, H. J. Cha, Pharmacology 2010, 85, 68.
A. Ilhan, M. A. Aladag, A. Kocer, A. Boluk, A. Gurel, F. Armutcu, Brain Res. Bull. 2005, 65, 495.
R. J. Racine, Electroencephalogr. Clin. Neurophysiol. 1972, 32, 281.
E. Beutler, Glutathione in Red Cell Metabolism, A Manual of Biochemical Methods, 2nd ed., Grune and Stratton, New York 1975, pp. 112.
A. Ledwozyw, J. Michalak, A. Stepień, A. Kadziołka, Clin. Chim. Acta 1986, 155, 275.
K. Walter, C. Schütt, Methods Enzymatic Analysis, 2nd ed., Academic Press, New York, NY 1974, p. 856.
H. Wei, K. Frenkel, Cancer Res. 1991, 51, 4443.
E. D. Corte, F. Stirpe, Biochem. J. 1968, 108, 349.
G. L. Ellman, K. D. Courtney, V. Andres, R. M. Featherstone, Biochem. Pharmacol. 1961, 7, 88.
H. Aebi, Methods Enzymol. 1984, 105, 121.
A. A. Mylroie, H. Collins, C. Umbles, J. Kyle, Toxicol. Appl. Pharmacol. 1986, 82, 512.
A. Wendel, Methods Enzymol. 1981, 77, 325.
E. Beutler, Red Cell Metabolism, A Manual of Biochemical Methods, 12, Academic Press, London 1971, p. 68.
O. Erel, Clin. Biochem. 2004, 37, 277.
O. Erel, Clin. Biochem. 2005, 38, 1103.
Y. Zhang, J. Chen, H. Ji, Z. G. Xiao, P. Shen, L. H. Xu, BMC Complement. Altern. Med. 2018, 18, 343.
K. M. Miranda, M. G. Espey, D. A. Wink, Nitric Oxide 2001, 5, 62.
O. H. Lowry, H. J. Rosebrough, A. L. Farr, R. J. Randall, J. Biol. Chem. 1951, 193, 265.
I. M. Ramzan, G. Levy, J. Pharmacol. Exp. Ther. 1985, 234, 624.
M. O. Dillioglugil, H. M. Kir, C. Demir, G. Ilbay, D. Sahin, O. Dillioglugil, G. Bambal, H. Mekik, N. Ates, Brain Res. Bull. 2010, 83, 356.
P. Uma Devi, A. Manocha, D. Vohora, Expert Opin. Pharmacother. 2008, 9, 3169.
Z. Kiasalari, M. Khalili, M. Roghani, A. Sadeghian, Iran. J. Pharm. Res. 2012, 11, 1209.
P. Uma Devi, K. K. Pillai, D. Vohora, Fundam. Clin. Pharmacol. 2006, 20, 247.
G. C. Militão, P. M. Ferreira, R. M. de Freitas, Neurochem. Int. 2010, 56, 16.
R. Janáky, K. Ogita, B. A. Pasqualotto, J. S. Bains, S. S. Oja, Y. Yoneda, C. A. Shaw, J. Neurochem. 1999, 73, 889.
N. Rishitha, A. Muthuraman, Life Sci. 2018, 199, 80.
X. Y. Mao, H. H. Zhou, W. L. Jin, Front. Neurosci. 2019, 13, 721.
P. Brust, A. Bech, R. Kretzschmar, R. Bergmann, Peptides 1994, 15, 1085.
H. Yorulmaz, F. B. Seker, G. Demir, I. E. Yalçın, B. Oztaş, Biol. Trace Elem. Res. 2013, 151, 256.
T. Koyuncuoğlu, C. Vızdıklar, D. Üren, H. Yılmaz, Ç. Yıldırım, S. S. Atal, D. Akakın, E. Kervancıoğlu Demirci, M. Yüksel, B. Ç. Yeğen, Peptides 2017, 90, 37.
L. M. Rambo, L. R. Ribeiro, I. D. Della-Pace, D. N. Stamm, R. da Rosa Gerbatin, M. Prigol, S. Pinton, C. W. Nogueira, A. F. Furian, M. S. Oliveira, M. R. Fighera, L. F. Royes, Amino Acids 2013, 44, 857.
S. Gezginci-Oktayoglu, I. B. Turkyilmaz, M. Ercin, R. Yanardag, S. Bolkent, Protoplasma 2016, 253, 127.
J. R. Cooper, F. E. Bloom, R. H. Roth, Acetylcholine, The Biochemical Basis of Neuropharmacology, Oxford University Press, New York 2003.
R. Gersner, D. Ekstein, S. C. Dhamne, S. C. Schachter, A. Rotenberg, Epilepsy Res. 2015, 117, 97.
D. C. S. Soares, J. L. R. Portela, D. H. Roos, N. R. Rodrigues, K. K. Gomes, G. E. Macedo, T. Posser, J. L. Franco, W. Hassan, R. L. Puntel, Mol. Cell. Biochem. 2018, 442, 129.
A. Akıncıoğlu, H. Akıncıoğlu, İ. Gülçin, S. Durdagi, C. T. Supuran, S. Göksu, Bioorg. Med. Chem. 2015, 23, 3592.
D. Osmaniye, B. N. Sağlık, U. Acar Çevik, S. Levent, B. Kaya Çavuşoğlu, Y. Özkay, Z. A. Kaplancıklı, G. Turan, Molecules 2019, 24, 2392.
E. J. Shin, J. H. Jeong, Y. H. Chung, W. K. Kim, K. H. Ko, J. H. Bach, J. S. Hong, Y. Yoneda, H. C. Kim, Neurochem. Int. 2011, 59, 122.
S. Waldbaum, M. Patel, J. Bioenerg. Biomembr. 2010, 42, 449.
M. Méndez-Armenta, C. Nava-Ruíz, D. Juárez-Rebollar, E. Rodríguez-Martínez, P. Y. Gómez, Oxid. Med. Cell Longev. 2014, 2014, 293689.
M. Raukas, R. Rebane, R. Mahlapuu, V. Jefremov, K. Zilmer, E. Karelson, N. Bogdanovic, M. Zilmer, Free Radic. Res. 2012, 46, 1490.
I. B. Turkyilmaz, R. Yanardag, Bulg. Chem. Commun. 2019, 51, 20.
F. Oztay, S. Tunali, O. Kayalar, R. Yanardag, J. Biochem. Mol. Toxicol. 2020, 34, e22602.
G. A. Rameau, D. S. Tukey, E. D. Garcin-Hosfield, R. F. Titcombe, C. Misra, L. Khatri, E. D. Getzoff, E. B. Ziff, J. Neurosci. 2007, 27, 3445.
H. Faghir-Ghanesefat, H. Keshavarz-Bahaghighat, N. Rajai, T. Mokhtari, E. Bahramnejad, S. Kazemi Roodsari, A. R. Dehpour, J. Mol. Neurosci. 2019, 7, 477.
I. B. Turkyilmaz, B. Bilgin Sokmen, R. Yanardag, J. Biochem. Mol. Toxicol. 2020, 34, e22580.
T. Shekh-Ahmad, S. Kovac, A. Y. Abramov, M. C. Walker, Epilepsy Behav. 2019, 101, 106410.
R. Olowe, S. Sandouka, A. Saadi, T. Shekh-Ahmad, Antioxidants 2020, 9, 990.
S. Kovac, A. T. Dinkova Kostova, A. M. Herrmann, N. Melzer, S. G. Meuth, A. Gorji, Int. J. Mol. Sci. 2017, 18, 1935.
S. Kovac, A. M. Domijan, M. C. Walker, A. Y. Abramov, J. Cell Sci. 2012, 125, 1796.
H. Girouard, G. Wang, E. F. Gallo, J. Anrather, P. Zhou, V. M. Pickel, C. Iadecola, J. Neurosci. 2009, 29, 2545.
A. M. Brennan, S. W. Suh, S. J. Won, P. Narasimhan, T. M. Kauppinen, H. Lee, Y. Edling, P. H. Chan, R. A. Swanson, Nat. Neurosci. 2009, 12, 857.
N. Onul, O. Ertik, N. Mermer, R. Yanardag, J. Biochem. Mol. Toxicol. 2018, 32, e22021.
D. Özerkan, O. Ertik, B. Kaya, S. E. Kuruca, R. Yanardag, B. Ulkuseven, Invest. New Drug. 2019, 37, 1187.