Reduced fractional anisotropy in bipolar disorder

Humans Bipolar Disorder / diagnostic imaging Depressive Disorder, Major / diagnostic imaging Diffusion Tensor Imaging / methods Anisotropy Cross-Sectional Studies White Matter / diagnostic imaging Mania
Bipolar disorder diffusion tensor imaging major depressive disorder mood state trait white matter microstructure

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
07 2023
Historique:
medline: 13 9 2023
pubmed: 15 7 2022
entrez: 14 7 2022
Statut: ppublish

Résumé

Patients with bipolar disorder (BD) show reduced fractional anisotropy (FA) compared to patients with major depressive disorder (MDD). Little is known about whether these differences are mood state-independent or influenced by acute symptom severity. Therefore, the aim of this study was (1) to replicate abnormalities in white matter microstructure in BD In this cross-sectional diffusion tensor imaging study, Analyses revealed a main effect of diagnosis on FA across all three groups ( Results indicated that the difference between BD and MDD was independent of depressive and manic symptom severity and mood state. Disruptions in white matter microstructure in BD might be a trait effect of the disorder. The potential of FA values to be used as a biomarker to differentiate BD from MDD should be further addressed in future studies using longitudinal designs.

Sections du résumé

BACKGROUND
Patients with bipolar disorder (BD) show reduced fractional anisotropy (FA) compared to patients with major depressive disorder (MDD). Little is known about whether these differences are mood state-independent or influenced by acute symptom severity. Therefore, the aim of this study was (1) to replicate abnormalities in white matter microstructure in BD
METHODS
In this cross-sectional diffusion tensor imaging study,
RESULTS
Analyses revealed a main effect of diagnosis on FA across all three groups (
CONCLUSIONS
Results indicated that the difference between BD and MDD was independent of depressive and manic symptom severity and mood state. Disruptions in white matter microstructure in BD might be a trait effect of the disorder. The potential of FA values to be used as a biomarker to differentiate BD from MDD should be further addressed in future studies using longitudinal designs.

Identifiants

DOI: 10.1017/S0033291722001490 PMID: 35833369 PMC: PMC10388324
pubmed: 35833369
doi: 10.1017/S0033291722001490
pii: S0033291722001490
pmc: PMC10388324
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4592-4602

Auteurs

Katharina Thiel (K)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Susanne Meinert (S)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Institute of Translational Neuroscience, University of Münster, Münster, Germany.

Alexandra Winter (A)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Hannah Lemke (H)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Lena Waltemate (L)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Fabian Breuer (F)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Marius Gruber (M)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Ramona Leenings (R)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Lucia Wüste (L)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Kathrin Rüb (K)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Julia-Katharina Pfarr (JK)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Frederike Stein (F)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Katharina Brosch (K)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Tina Meller (T)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Kai Gustav Ringwald (KG)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Igor Nenadić (I)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Axel Krug (A)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.

Jonathan Repple (J)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Nils Opel (N)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Katharina Koch (K)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Elisabeth J Leehr (EJ)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Jochen Bauer (J)

Department of Clinical Radiology, University of Muenster, Muenster, Germany.

Dominik Grotegerd (D)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Tim Hahn (T)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Tilo Kircher (T)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Udo Dannlowski (U)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.
ORCID: 0000-0002-0623-3759

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Phénomènes chimiques › Anisotropie › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Reduced fractional anisotropy in bipolar disorder
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Manie › Reduced fractional anisotropy in bipolar disorder