State transitions in the statistically stable place cell population correspond to rate of perceptual change.
Weber’s law
dorsal CA1
hippocampus
homeostasis
information theory
large environment
perception
place cells
single-unit
spatial memory
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
22 08 2022
22 08 2022
Historique:
received:
23
09
2021
revised:
20
04
2022
accepted:
15
06
2022
pubmed:
15
7
2022
medline:
26
8
2022
entrez:
14
7
2022
Statut:
ppublish
Résumé
The hippocampus occupies a central role in mammalian navigation and memory. Yet an understanding of the rules that govern the statistics and granularity of the spatial code, as well as its interactions with perceptual stimuli, is lacking. We analyzed CA1 place cell activity recorded while rats foraged in different large-scale environments. We found that place cell activity was subject to an unexpected but precise homeostasis-the distribution of activity in the population as a whole being constant at all locations within and between environments. Using a virtual reconstruction of the largest environment, we showed that the rate of transition through this statistically stable population matches the rate of change in the animals' visual scene. Thus, place fields near boundaries were small but numerous, while in the environment's interior, they were larger but more dispersed. These results indicate that hippocampal spatial activity is governed by a small number of simple laws and, in particular, suggest the presence of an information-theoretic bound imposed by perception on the fidelity of the spatial memory system.
Identifiants
pubmed: 35835121
pii: S0960-9822(22)01008-9
doi: 10.1016/j.cub.2022.06.046
pmc: PMC9616721
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3505-3514.e7Subventions
Organisme : Wellcome Trust
ID : 212281/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Nature. 2022 Feb;602(7897):461-467
pubmed: 35140401
Nature. 2015 Feb 12;518(7538):232-235
pubmed: 25673417
Nature. 2015 Feb 12;518(7538):207-12
pubmed: 25673414
Nat Neurosci. 2007 Jun;10(6):682-4
pubmed: 17486102
Science. 2008 Jul 4;321(5885):140-3
pubmed: 18599792
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10244-10249
pubmed: 28874578
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18428-35
pubmed: 25489089
Nature. 2003 Sep 11;425(6954):184-8
pubmed: 12968182
J Neurophysiol. 2016 Aug 1;116(2):868-91
pubmed: 27193320
Curr Biol. 2021 May 24;31(10):2178-2190.e6
pubmed: 33770492
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):378-83
pubmed: 23256159
Hippocampus. 2020 Dec;30(12):1347-1355
pubmed: 32584491
Curr Biol. 2020 Apr 20;30(8):1397-1409.e7
pubmed: 32109393
Science. 2016 Mar 25;351(6280):1440-3
pubmed: 27013730
Science. 2013 Apr 19;340(6130):367-72
pubmed: 23599496
J Neurosci. 1997 Aug 1;17(15):5900-20
pubmed: 9221787
J Neurosci. 2000 Oct 1;20(19):7463-77
pubmed: 11007906
J Neurosci. 1998 Oct 15;18(20):8455-66
pubmed: 9763488
J Neurophysiol. 1998 Feb;79(2):1017-44
pubmed: 9463459
Neural Comput. 2012 Sep;24(9):2280-317
pubmed: 22594833
Neuron. 2013 Jun 19;78(6):1090-101
pubmed: 23707613
Science. 2021 May 28;372(6545):
pubmed: 34045327
J Neurophysiol. 2004 May;91(5):2259-72
pubmed: 14736863
Neuron. 2001 Oct 11;32(1):141-9
pubmed: 11604145
Nat Neurosci. 1998 May;1(1):36-41
pubmed: 10195106
Philos Trans R Soc Lond B Biol Sci. 1997 Oct 29;352(1360):1535-43
pubmed: 9368942
Elife. 2018 Oct 22;7:
pubmed: 30346272
J Neurosci. 1990 Jun;10(6):2008-17
pubmed: 2355262
Cell. 2020 Oct 29;183(3):620-635.e22
pubmed: 33035454
J Neurosci. 1998 Mar 1;18(5):1818-26
pubmed: 9465006
Elife. 2019 Mar 01;8:
pubmed: 30822270
Science. 2014 Aug 15;345(6198):814-7
pubmed: 25124440
Neural Comput. 2014 Nov;26(11):2379-94
pubmed: 25149694
Neural Comput. 2006 Jul;18(7):1511-26
pubmed: 16764512
Behav Neurosci. 1997 Feb;111(1):20-34
pubmed: 9109621
Nature. 1996 May 30;381(6581):425-8
pubmed: 8632799
Nat Neurosci. 2017 Nov;20(11):1643-1653
pubmed: 28967910
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
J Neurosci. 1994 Dec;14(12):7235-51
pubmed: 7996172
PLoS One. 2011;6(7):e22349
pubmed: 21789250
Cereb Cortex. 2015 Jan;25(1):10-25
pubmed: 23945240
Hippocampus. 2007;17(9):786-800
pubmed: 17598149
Exp Brain Res. 1997 Oct;117(1):131-42
pubmed: 9386011
J Neurosci Methods. 2003 Aug 15;127(2):123-35
pubmed: 12906942
Brain Res. 1971 Nov;34(1):171-5
pubmed: 5124915
J Neurosci. 2003 Oct 1;23(26):8827-35
pubmed: 14523083
Neuron. 2015 May 6;86(3):827-39
pubmed: 25892299
Hippocampus. 2000;10(4):369-79
pubmed: 10985276
J Neural Eng. 2017 Aug;14(4):045003
pubmed: 28169219
J Neurosci. 1995 Jul;15(7 Pt 2):5249-62
pubmed: 7623149
Hippocampus. 2005;15(7):841-52
pubmed: 16145692
Rev Neurosci. 2006;17(1-2):71-97
pubmed: 16703944
Science. 1993 Aug 20;261(5124):1055-8
pubmed: 8351520
Nat Commun. 2019 Feb 7;10(1):630
pubmed: 30733457
J Neurosci. 2008 Oct 29;28(44):11250-62
pubmed: 18971467
Neuron. 2017 Nov 15;96(4):925-935.e6
pubmed: 29056296
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20130290
pubmed: 24366144
Curr Biol. 2019 Mar 18;29(6):1047-1054.e3
pubmed: 30853431
Neural Comput. 1999 Jan 1;11(1):75-84
pubmed: 9950722