Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.

Alzheimer Disease / complications Amyloid beta-Peptides / genetics Amyloid beta-Protein Precursor / genetics Animals Brain / metabolism Disease Models, Animal Down Syndrome / complications Female Humans Male Mice
BACE2 DYRK1A Down syndrome amyloid precursor protein amyloid-β

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
17 08 2022
Historique:
received: 15 03 2022
revised: 03 06 2022
accepted: 18 06 2022
pubmed: 15 7 2022
medline: 20 8 2022
entrez: 14 7 2022
Statut: ppublish

Résumé

Individuals who have Down syndrome (DS) frequently develop early onset Alzheimer's disease (AD), a neurodegenerative condition caused by the buildup of aggregated amyloid-β (Aβ) and tau proteins in the brain. Aβ is produced by amyloid precursor protein (

Identifiants

DOI: 10.1523/JNEUROSCI.0521-22.2022 PMID: 35835549 PMC: PMC9398545
pubmed: 35835549
pii: JNEUROSCI.0521-22.2022
doi: 10.1523/JNEUROSCI.0521-22.2022
pmc: PMC9398545
mid: EMS154768
doi:

Substances chimiques

Amyloid beta-Peptides 0
Amyloid beta-Protein Precursor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6453-6468

Subventions

Organisme : Cancer Research UK
ID : FC001194
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001194
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098328
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001194
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001194
Pays : United Kingdom

Informations de copyright

Copyright © 2022 the authors.

Références

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Auteurs

Paige Mumford (P)

The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom.
ORCID: 0000-0003-0163-0760

Justin Tosh (J)

Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.

Silvia Anderle (S)

The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom.

Eleni Gkanatsiou Wikberg (E)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden.

Gloria Lau (G)

The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom.

Sue Noy (S)

Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.

Karen Cleverley (K)

Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.

Takashi Saito (T)

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama Japan, 351-0198.
ORCID: 0000-0002-9659-9251

Takaomi C Saido (TC)

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama Japan, 351-0198.
ORCID: 0000-0003-1970-6903

Eugene Yu (E)

Genetics and Genomics Program and Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Children's Guild Foundation Down Syndrome Research Program, Buffalo, New York NY 14263.

Gunnar Brinkmalm (G)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden.

Erik Portelius (E)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden.

Kaj Blennow (K)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-43180, Sweden.

Henrik Zetterberg (H)

The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg S-431 80, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-43180, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.

Victor Tybulewicz (V)

The Francis Crick Institute, London, NW1 1AT, United Kingdom.
Department of Immunology and Inflammation, Imperial College, London, W12 0NN, United Kingdom.
LonDownS: London Down Syndrome Consortium.
ORCID: 0000-0003-2439-0798

Elizabeth M C Fisher (EMC)

Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom elizabeth.fisher@ucl.ac.uk f.wiseman@ucl.ac.uk.
LonDownS: London Down Syndrome Consortium.

Frances K Wiseman (FK)

The UK Dementia Research Institute, University College London, London, WC1N 3BG, United Kingdom elizabeth.fisher@ucl.ac.uk f.wiseman@ucl.ac.uk.
LonDownS: London Down Syndrome Consortium.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Eucaryotes › Animaux › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies chromosomiques › Syndrome de Down › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Mapping of APP and Amyloid-β Biology...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Genetic Mapping of APP and Amyloid-β Biology...