Past, present, and future of Lyme disease vaccines: antigen engineering approaches and mechanistic insights.
Antigen design
Borrelia
Lyme borreliae
genetic engineering
Journal
Expert review of vaccines
ISSN: 1744-8395
Titre abrégé: Expert Rev Vaccines
Pays: England
ID NLM: 101155475
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
pubmed:
16
7
2022
medline:
1
10
2022
entrez:
15
7
2022
Statut:
ppublish
Résumé
Transmitted by ticks, Lyme disease is the most common vector-borne disease in the Northern hemisphere. Despite the geographical expansion of human Lyme disease cases, no effective preventive strategies are currently available. Developing an efficacious and safe vaccine is therefore urgently needed. Efforts have previously been taken to identify vaccine targets in the causative pathogen ( In this review, we summarize the antigen engineering approaches that have been applied to overcome those challenges and the underlying mechanisms that can be exploited to improve both safety and efficacy of future Lyme disease vaccines. Over the past two decades, several new genetically redesigned Lyme disease vaccine candidates have shown success in both preclinical and clinical settings and built a solid foundation for further development. These studies have greatly informed the protective mechanisms of reducing Lyme disease burdens and ending the endemic of this disease.
Identifiants
pubmed: 35836340
doi: 10.1080/14760584.2022.2102484
pmc: PMC9529901
mid: NIHMS1827947
doi:
Substances chimiques
Lyme Disease Vaccines
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1405-1417Subventions
Organisme : NIAID NIH HHS
ID : R21 AI144891
Pays : United States
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