A double-blinded, randomized, parallel intervention to evaluate biomarker-based nutrition plans for weight loss: The PREVENTOMICS study.

Adult Biomarkers Body Mass Index Body Weight Humans Lipids Obesity / therapy Overweight / therapy Weight Loss

Health-biomarkers Metabolomics Nutrigenetics Obesity Personalized nutrition Precision nutrition Weight management

Journal

Clinical nutrition (Edinburgh, Scotland)

ISSN: 1532-1983

Titre abrégé: Clin Nutr

Pays: England

ID NLM: 8309603

Informations de publication

Date de publication:
08 2022

Historique:

received: 20 04 2022

revised: 14 06 2022

accepted: 20 06 2022

pubmed: 16 7 2022

medline: 5 8 2022

entrez: 15 7 2022

Statut: ppublish

Résumé

Growing evidence suggests that biomarker-guided dietary interventions can optimize response to treatment. In this study, we evaluated the efficacy of the PREVENTOMCIS platform-which uses metabolomic and genetic information to classify individuals into different 'metabolic clusters' and create personalized dietary plans-for improving health outcomes in subjects with overweight or obesity. A 10-week parallel, double-blinded, randomized intervention was conducted in 100 adults (82 completers) aged 18-65 years, with body mass index ≥27 but <40 kg/m There were significant main effects of time (P < 0.01), but no group main effects, or time-by-group interactions, for the change in fat mass (personalized: -2.1 [95% CI -2.9, -1.4] kg; control: -2.0 [95% CI -2.7, -1.3] kg) and body weight (personalized: -3.1 [95% CI -4.1, -2.1] kg; control: -3.3 [95% CI -4.2, -2.4] kg). The difference between groups in fat mass change was -0.1 kg (95% CI -1.2, 0.9 kg, P = 0.77). Both diets resulted in significant improvements in insulin resistance and lipid profile, but there were no significant differences between groups. Personalized dietary plans did not result in greater benefits over a generic, but generally healthy diet, in this 10-week clinical trial. Further studies are required to establish the soundness of different precision nutrition approaches, and translate this science into clinically relevant dietary advice to reduce the burden of obesity and its comorbidities. ClinicalTrials.gov registry (NCT04590989).

Sections du résumé

BACKGROUND & AIMS

METHODS

A 10-week parallel, double-blinded, randomized intervention was conducted in 100 adults (82 completers) aged 18-65 years, with body mass index ≥27 but <40 kg/m

RESULTS

There were significant main effects of time (P < 0.01), but no group main effects, or time-by-group interactions, for the change in fat mass (personalized: -2.1 [95% CI -2.9, -1.4] kg; control: -2.0 [95% CI -2.7, -1.3] kg) and body weight (personalized: -3.1 [95% CI -4.1, -2.1] kg; control: -3.3 [95% CI -4.2, -2.4] kg). The difference between groups in fat mass change was -0.1 kg (95% CI -1.2, 0.9 kg, P = 0.77). Both diets resulted in significant improvements in insulin resistance and lipid profile, but there were no significant differences between groups.

CONCLUSION

Personalized dietary plans did not result in greater benefits over a generic, but generally healthy diet, in this 10-week clinical trial. Further studies are required to establish the soundness of different precision nutrition approaches, and translate this science into clinically relevant dietary advice to reduce the burden of obesity and its comorbidities.

CLINICAL TRIAL REGISTRY

ClinicalTrials.gov registry (NCT04590989).

Identifiants

DOI: 10.1016/j.clnu.2022.06.032 PMID: 35839545

pubmed: 35839545

pii: S0261-5614(22)00226-6

doi: 10.1016/j.clnu.2022.06.032

pii:

doi:

Substances chimiques

Biomarkers 0

Lipids 0

Banques de données

ClinicalTrials.gov

['NCT04590989']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1834-1844

Informations de copyright

Déclaration de conflit d'intérêts

Conflict of interest SMOG is an employee of Simple Feast (Copenhagen, Denmark) that provided food as study material. The remaining authors declare no conflicts of interest.