Transmission history of SARS-CoV-2 in humans and white-tailed deer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 07 2022
15 07 2022
Historique:
received:
26
04
2022
accepted:
04
07
2022
entrez:
15
7
2022
pubmed:
16
7
2022
medline:
20
7
2022
Statut:
epublish
Résumé
The emergence of a novel pathogen in a susceptible population can cause rapid spread of infection. High prevalence of SARS-CoV-2 infection in white-tailed deer (Odocoileus virginianus) has been reported in multiple locations, likely resulting from several human-to-deer spillover events followed by deer-to-deer transmission. Knowledge of the risk and direction of SARS-CoV-2 transmission between humans and potential reservoir hosts is essential for effective disease control and prioritisation of interventions. Using genomic data, we reconstruct the transmission history of SARS-CoV-2 in humans and deer, estimate the case finding rate and attempt to infer relative rates of transmission between species. We found no evidence of direct or indirect transmission from deer to human. However, with an estimated case finding rate of only 4.2%, spillback to humans cannot be ruled out. The extensive transmission of SARS-CoV-2 within deer populations and the large number of unsampled cases highlights the need for active surveillance at the human-animal interface.
Identifiants
pubmed: 35840592
doi: 10.1038/s41598-022-16071-z
pii: 10.1038/s41598-022-16071-z
pmc: PMC9284484
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
12094Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M011194/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R21 AI156406
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134911
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00076
Pays : United States
Informations de copyright
© 2022. The Author(s).
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