An insight into the interaction between Indisulam and human serum albumin: Spectroscopic method, computer simulation and in vitro cytotoxicity assay.
Computer simulation
Cytotoxicity
Esterase-like activity
Human serum albumin
Indisulam
Molecular glue
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
29
04
2022
revised:
24
06
2022
accepted:
07
07
2022
pubmed:
17
7
2022
medline:
16
8
2022
entrez:
16
7
2022
Statut:
ppublish
Résumé
Indisulam (IDM) is a sulfanilamide anticancer agent and has been identified as a molecular glue recently. It shows potential for novel therapies development and brings more hope for curing human diseases. The affinity between molecular glues and plasma protein makes it significant to understand the characteristics of such substances. Therefore, the interaction between IDM and human serum albumin (HSA) was explored through solvent experiments, computer simulation experiments, enzyme kinetics experiments, and cell viability assay. The results revealed that IDM and HSA spontaneously formed stable binary complex with the binding constant of the order 10
Identifiants
pubmed: 35841666
pii: S0045-2068(22)00423-0
doi: 10.1016/j.bioorg.2022.106017
pii:
doi:
Substances chimiques
N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide
0
Solvents
0
Sulfonamides
0
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106017Informations de copyright
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