Inhibitory effects of oat peptides on lipolysis: A physicochemical perspective.

Avena / metabolism Bile Acids and Salts Digestion Emulsions / chemistry Lipase / metabolism Lipolysis Peptides / metabolism Triglycerides / chemistry
Contact angle Emulsion stability Lipase inhibition Lipid digestion Proteomics Rheological properties

Journal

Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639

Informations de publication

Date de publication:
01 Dec 2022
Historique:
received: 12 01 2022
revised: 21 05 2022
accepted: 28 06 2022
pubmed: 17 7 2022
medline: 30 8 2022
entrez: 16 7 2022
Statut: ppublish

Résumé

Studies on the control of lipid digestion by food-derived active substances have prioritized the direct inhibition of lipase, ignoring the influence of these substances on the stability of bile salt (BS)-stabilized oil emulsions, which are essential for the hydrolysis of triglycerides by lipase. This study aimed to demonstrate the inhibitory potential of oat peptides (OPs) on lipolysis due to lipase inhibition, in particular, the physicochemical destruction of BS-stabilized emulsions. OPs were characterized by an enterostatin-like X-Pro-Y-Pro-Arg terminal sequence, competitively and/or noncompetitively inhibited lipase, and even caused lipase conformational changes. Interestingly, OPs destabilized BS-stabilized emulsions by weakening the rheological cross-linking structure of the emulsions through competitive hydrophobic binding to BS. Further analysis revealed that the H-bond binding of OP to BS significantly destroyed the hydrophilic and lipophilic balance of BS by increasing the surface hydrophobicity. These findings provided novel insights into the action mechanism of bioactive peptides on lipid digestion.

Identifiants

DOI: 10.1016/j.foodchem.2022.133621 PMID: 35841683
pubmed: 35841683
pii: S0308-8146(22)01583-7
doi: 10.1016/j.foodchem.2022.133621
pii:
doi:

Substances chimiques

Bile Acids and Salts 0
Emulsions 0
Peptides 0
Triglycerides 0
Lipase EC 3.1.1.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

133621

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Yaqiong Zhang (Y)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Xiaomin Tang (X)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Feiyang Li (F)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Junping Zhang (J)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Bo Zhang (B)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Xin Yang (X)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Yingxue Tang (Y)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

Yanyan Zhang (Y)

Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China.

Junfeng Fan (J)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China. Electronic address: fanjunfeng@bjfu.edu.cn.

Bolin Zhang (B)

College of Biological Sciences and Technology, Beijing Key Laboratory of Food Processing and Safety in Forestry, Beijing Forestry University, Beijing 100083, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Poaceae › Avena › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Acides et sels biliaires › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Digestion › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Émulsions › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Triacylglycerol lipase › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Lipolyse › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Inhibitory effects of oat peptides on...
questionsmedicales.fr › Lipides › Glycérides › Triglycéride › Inhibitory effects of oat peptides on...