Resolving SARS-CoV-2 CD4
CD4 T cells
COVID-19
T cell receptor
TCR repertoire
epitope discovery
public T cell response
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
16 08 2022
16 08 2022
Historique:
received:
18
11
2021
revised:
08
05
2022
accepted:
24
06
2022
pubmed:
17
7
2022
medline:
20
8
2022
entrez:
16
7
2022
Statut:
ppublish
Résumé
The current strategy to detect immunodominant T cell responses focuses on the antigen, employing large peptide pools to screen for functional cell activation. However, these approaches are labor and sample intensive and scale poorly with increasing size of the pathogen peptidome. T cell receptors (TCRs) recognizing the same epitope frequently have highly similar sequences, and thus, the presence of large sequence similarity clusters in the TCR repertoire likely identify the most public and immunodominant responses. Here, we perform a meta-analysis of large, publicly available single-cell and bulk TCR datasets from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals to identify public CD4
Identifiants
pubmed: 35841887
pii: S2666-3791(22)00233-6
doi: 10.1016/j.xcrm.2022.100697
pmc: PMC9247234
pii:
doi:
Substances chimiques
Epitopes
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
100697Subventions
Organisme : NIAID NIH HHS
ID : F32 AI157296
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests P.B. and A.S. are consultants of Miltenyi Biotec, who own IP rights concerning parts of the ARTE technology. P.G.T. has consulted and/or received honoraria and travel support from Illumina, Johnson and Johnson, and 10X Genomics. P.G.T. serves on the Scientific Advisory Board of Immunoscape and Cytoagents. The authors have applied for patents covering some aspects of these studies.
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