Convalescent plasma - An insight into a novel treatment of covid-19 ICU patients.
Convalescent Plasma
Guidelines
ICU
Tocilizumab
Journal
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
ISSN: 1473-0502
Titre abrégé: Transfus Apher Sci
Pays: England
ID NLM: 101095653
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
31
05
2022
revised:
25
06
2022
accepted:
29
06
2022
pubmed:
17
7
2022
medline:
6
12
2022
entrez:
16
7
2022
Statut:
ppublish
Résumé
Various therapies have been tried for Covid disease including the use of antivirals, steroids, monoclonal antibodies and convalescent plasma. The study was conducted on convalescent plasma transfused ICU patients. Part A of the study involves clinical outcomes based on gender, age, comorbidities, blood group,and the average length of stay. Part B investigates clinical outcomes in patients transfused with convalescent plasma before and after the November 2021 guidelines. Part C of the study includes patients in cytokine storm and the efficacy of tocilizumab in these patients. Out of the 326 ICU patients transfused with convalescent plasma the overall mortality was 152 (53.3 %). On comparing blood groups and clinical outcomes, a clinically significant result was found. A clinically significant association was also seen on comparing the clinical outcome of 18-50 years and 61-70 years age group and in female gender patients. The average number of ICU days had a positive impact on the overall patient survival. Out of the patients in 'cytokine storm' (n = 109), on day 20, the survival percentage in the non-Tocilizumab group showed a downward trend throughout. However, in the Tocilizumab group, the survival percentage remained stable throughout till around day 50. Amongst the convalescent plasma transfused ICU patients, females, having blood group B, and an average length of stay of fewer than 20 days had a better chance of survival. The patients given tocilizumab and convalescent plasma had a better chance of survival compared to tocilizumab alone.
Identifiants
pubmed: 35842293
pii: S1473-0502(22)00178-1
doi: 10.1016/j.transci.2022.103497
pmc: PMC9247114
pii:
doi:
Substances chimiques
Blood Group Antigens
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Pagination
103497Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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